In silico Mechanics of Stem Cells Intramyocardially Transplanted with a Biomaterial Injectate for Treatment of Myocardial Infarction.

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Engineering and Technology Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI:10.1007/s13239-024-00734-1

Y D Motchon, K L Sack, M S Sirry, N J Nchejane, T Abdalrahman, J Nagawa, M Kruger, E Pauwels, D Van Loo, A De Muynck, L Van Hoorebeke, N H Davies, T Franz

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Abstract

Purpose: Biomaterial and stem cell delivery are promising approaches to treating myocardial infarction. However, the mechanical and biochemical mechanisms underlying the therapeutic benefits require further clarification. This study aimed to assess the deformation of stem cells injected with the biomaterial into the infarcted heart.

Methods: A microstructural finite element model of a mid-wall infarcted myocardial region was developed from ex vivo microcomputed tomography data of a rat heart with left ventricular infarct and intramyocardial biomaterial injectate. Nine cells were numerically seeded in the injectate of the microstructural model. The microstructural and a previously developed biventricular finite element model of the same rat heart were used to quantify the deformation of the cells during a cardiac cycle for a biomaterial elastic modulus (E_inj) ranging between 4.1 and 405,900 kPa.

Results: The transplanted cells' deformation was largest for E_inj = 7.4 kPa, matching that of the cells, and decreased for an increase and decrease in E_inj. The cell deformation was more sensitive to E_inj changes for softer (E_inj ≤ 738 kPa) than stiffer biomaterials.

Conclusions: Combining the microstructural and biventricular finite element models enables quantifying micromechanics of transplanted cells in the heart. The approach offers a broader scope for in silico investigations of biomaterial and cell therapies for myocardial infarction and other cardiac pathologies.

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用生物材料注射液治疗心肌梗死的心肌内干细胞移植模拟力学

目的：生物材料和干细胞输送是治疗心肌梗塞的有效方法。然而，其治疗效益背后的机械和生化机制需要进一步阐明。本研究旨在评估干细胞与生物材料一起注入梗死心脏后的变形情况：方法：根据大鼠心脏左心室梗死和心肌内生物材料注射的体外微计算机断层扫描数据，建立了中壁心肌梗死区域的微结构有限元模型。在微结构模型的注射液中以数值方式播种了九个细胞。在生物材料弹性模量（Einj）介于 4.1 和 405,900 kPa 之间的情况下，使用微结构模型和之前开发的同一大鼠心脏的双心室有限元模型来量化细胞在心动周期中的变形：移植细胞在 Einj = 7.4 kPa 时的变形量最大，与细胞的变形量相匹配，Einj 的增大和减小均使细胞变形量减小。与较硬的生物材料相比，较软的生物材料（Einj ≤ 738 kPa）的细胞变形对 Einj 的变化更为敏感：结论：结合微结构模型和双心室有限元模型，可以量化心脏移植细胞的微观力学。这种方法为心肌梗塞和其他心脏病的生物材料和细胞疗法的硅学研究提供了更广阔的空间。

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来源期刊

Cardiovascular Engineering and Technology Engineering-Biomedical Engineering

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Cardiovascular Engineering and Technology is a journal publishing the spectrum of basic to translational research in all aspects of cardiovascular physiology and medical treatment. It is the forum for academic and industrial investigators to disseminate research that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. Manuscripts spanning from subcellular to systems level topics are invited, including but not limited to implantable medical devices, hemodynamics and tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biologics, and sensors. In addition to manuscripts describing the original publication of research, manuscripts reviewing developments in these topics or their state-of-art are also invited.