The potential impact of dietary choices on melanoma risk: an anti-inflammatory diet.

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY Genes and Nutrition Pub Date : 2024-05-23 DOI:10.1186/s12263-024-00745-6
Cristina Fortes, Simona Mastroeni, Lauretta Levati, Massimo Alotto, Francesco Ricci, Stefania D'Atri
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引用次数: 0

Abstract

The role of inflammation in the aetiology of cancer is recognized. However, no study yet examined the association between an anti-inflammatory diet and cutaneous melanoma and explored whether it could be modified by genetic variations in cyclooxygenase-2 (COX-2), a key enzyme in inflammation. A case-control study was conducted in the IDI-IRCCS hospital in Rome, Italy with 273 cases of primary cutaneous melanoma and 269 controls frequency matched to cases. Information on socio-demographic and pigmentary characteristics, medical history, sun exposure and dietary habits were collected for all subjects. The - 765G > C polymorphism was identified in DNA extracted from blood samples. An anti-inflammatory diet score was created. Logistic regression models were fitted to obtain odds ratios (ORs) and 95% confidence intervals (CIs). A high anti-inflammatory diet score (≥ 8 anti-inflammatory dietary items) was associated with a decreased risk of cutaneous melanoma (OR: 0.29; 95%CI: 0.17-0.49, Ptrend < 0.0001) after adjusting for sex, age, education, number of common nevi, skin photo-type, solar lentigines and sunburns in childhood. COX-2 -765 G > C polymorphism was not an independent risk factor for cutaneous melanoma. Although interaction between - 765G > C genotypes and anti-inflammatory diet score was not statistically significant (p = 0.25), when stratified by -765 G > C genotypes the effect of the anti-inflammatory diet was slightly more pronounced for participants carrying - 765GG (OR: 0.17; 95%CI: 0.06-0.47, Ptrend < 0.001). Our study findings suggest that adherence to an anti-inflammatory diet is associated with a decreased risk of developing cutaneous melanoma. These results suggest the potential impact of dietary choices on melanoma risk.

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饮食选择对黑色素瘤风险的潜在影响:抗炎饮食。
炎症在癌症病因中的作用已得到公认。然而,目前还没有研究探讨抗炎饮食与皮肤黑色素瘤之间的关系,以及这种关系是否会因环氧合酶-2(COX-2)的基因变异而改变,环氧合酶-2是炎症中的一种关键酶。意大利罗马的 IDI-IRCCS 医院开展了一项病例对照研究,共发现 273 例原发性皮肤黑色素瘤病例和 269 例与病例频率匹配的对照组。研究人员收集了所有受试者的社会人口学特征、色素特征、病史、日晒和饮食习惯等信息。从血液样本中提取的 DNA 鉴定出了 - 765G > C 多态性。建立了抗炎饮食评分。通过拟合逻辑回归模型得出几率比(ORs)和 95% 置信区间(CIs)。在调整了性别、年龄、教育程度、常见痣的数量、皮肤光型、日光性色斑和儿童时期晒伤的因素后,高抗炎性饮食评分(≥ 8 项抗炎性饮食项目)与皮肤黑色素瘤风险降低相关(OR:0.29;95%CI:0.17-0.49,Ptrend < 0.0001)。COX-2 -765 G > C 多态性不是皮肤黑色素瘤的独立风险因素。虽然 -765G > C 基因型与抗炎饮食得分之间的交互作用在统计学上并不显著(P = 0.25),但如果按照 -765 G > C 基因型进行分层,抗炎饮食对携带 -765GG 基因型的参与者的影响略微明显(OR:0.17;95%CI:0.06-0.47,Ptrend < 0.001)。我们的研究结果表明,坚持抗炎饮食与患皮肤黑色素瘤的风险降低有关。这些结果表明了饮食选择对黑色素瘤风险的潜在影响。
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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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