Estimated Glomerular Filtration Rate Slope as an Endpoint in Cardiovascular Trials.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-25 DOI:10.1007/s11897-024-00668-8
Arsalan Hamid, Stephen J Greene, Ankit Mehta, Javed Butler, Muhammad Shahzeb Khan
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Abstract

Purpose of review: End stage kidney disease can be a slow process and it may be challenging to achieve required follow-up for sufficient events. Therefore, a surrogate kidney endpoint, such as estimated glomerular filtration rate (eGFR) slope maybe attractive to assess the kidney in cardiovascular trials, especially heart failure (HF).

Recent findings: eGFR slope can generate informative results in a shorter follow-up period, has decreased risk of type-2 error, and is less sensitive to eGFR shifts compared with other surrogate kidney endpoints (eGFR decline≥40% or doubling creatinine). However, eGFR slope has its limitations with acute effects, heterogeneity in slope calculation/reporting, and deviations from linearity. eGFR slope is a kidney endpoint which may be well-suited for HF trials. Cross-collaborated guideline recommendations are needed to optimize the use of eGFR slope as a kidney endpoint in patients with HF.

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将估计肾小球滤过率斜率作为心血管试验的终点。
审查目的:终末期肾病可能是一个缓慢的过程,要实现所需的充分事件随访可能具有挑战性。最近的研究结果:与其他替代肾脏终点(eGFR 下降≥40% 或肌酐翻倍)相比,eGFR 斜率能在较短的随访期内产生有参考价值的结果,减少 2 型错误的风险,对 eGFR 变化的敏感性较低。然而,eGFR 斜率也有其局限性,如急性效应、斜率计算/报告的异质性以及线性偏差等。为优化 eGFR 斜率作为肾脏终点在心房颤动患者中的应用,需要制定交叉合作的指南建议。
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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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