High Quality Au-carbon Nitride Catalyst for Monitoring of Anti-prostate Cancer Drug (Flutamide)

Abstract

Determination of anti-cancer drug in bio-fluids is an important task for human health care and clinical diagnosis. In this study, we developed a new voltammetric sensor using a nanocatalyst of gold nanoparticles decorated on carbon nitride (GNPs@CN). This electrochemical sensing device was employed for measuring of non-steroidal anti-inflammatory drug flutamide (FLT). Various charactrization and electro-catalytic methods were employed to investigate the morphological, crystal structural, chemical components, and catalytic properties of GNPs@CN composite material. The combination of CN nanosheets and GNPs facilitated the electron transfer at the interface sensing layer. The established sensor demonstrated a linear response to FLT concentrations ranging from 0.075 µM to 100 µM and excellent detection limit of 50 nM (based on the 3σ_b method). Furthermore, the proposed sensing platform depicts good selectivity, acceptable reproducibility, and high operational stability for electro-catalytic detection of FLT levels in real biological samples. The capability for real-time applications of the prepared sensor was also validated with an outstanding recovery rate (more than 97%) and good relative standard deviation (RSD) values (less than 3%) human fluids. This approach presents numerous benefits, such as ease of use, cost-effectiveness and rapid analysis for FLT monitoring in human body fluids.