K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

IF 4.7 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-21 DOI:10.26508/lsa.202402740
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Phillip Mertins, Thomas Sommer
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Abstract

Ubiquitin interactor pulldown coupled with mass spectrometry elucidates K48- and K63-linked interactomes including novel heterotypic branch- and chain length–specific binders. This screen lays the foundations for our understanding of how complex Ub architectures are read.
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与 K48 和 K63 链接的泛素链相互作用组揭示了分支和长度特异性泛素相互作用因子
泛素相互作用因子下拉与质谱联用技术阐明了 K48 和 K63 连接的相互作用组,包括新型异型分支和链长特异性结合体。这一筛选为我们了解如何读取复杂的 Ub 结构奠定了基础。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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