Glyphosate contamination of drinking water and the occurrence of oxidative stress: Exposure assessment to rural Brazilian populations

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-05-23 DOI:10.1016/j.etap.2024.104476

Rafaella Ferreira Nascimento Nunes , Luiz Paulo Aguiar Marciano , Geovana Sousa Oliveira , Naiane Silva Cardoso , Fernanda Borges de Araújo Paula , Marcia Sarpa , Isarita Martins

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Abstract

Studies reported that continuous application of glyphosate can cause disturbance in aquatic/terrestrial environments. As such, the objective of this study is to discuss the risk of exposure to the herbicide in drinking water and to assess the oxidative stress in the consumers rural populations of Casimiro de Abreu/ RJ and Paraguaçu/ MG, Brazil. For this, water samples (n=69) were analysed from the home of volunteers, by FMOC derivatizing- LC-FLD method. The oxidative stress was analysed determining lipid peroxidation (MAD) and defense enzymes (SOD and CAT) in serum samples from rural population (n=42) compared to urban residents (n= 42). Results of the analysis from drinking water, despite the low and moderate risk, by the hazard quotient (HQ), revealed that the population is environmentally exposed to the glyphosate. The relevant findings showed that is important to implement monitoring/ biomonitoring programs to prevent pollution and toxic effects in the rural populations.

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饮用水中的草甘膦污染与氧化应激的发生：巴西农村人口的接触评估

研究报告称，持续施用草甘膦会对水生/陆生环境造成干扰。因此，本研究的目的是讨论饮用水中接触除草剂的风险，并评估巴西卡西米罗-德阿布雷乌（Casimiro de Abreu/RJ）和帕拉瓜苏（Paraguaçu/MG）农村消费者的氧化应激情况。为此，采用 FMOC 衍生-LC-FLD 方法对志愿者家中的水样（n=69）进行了分析。通过测定农村居民（42 人）与城市居民（42 人）血清样本中的脂质过氧化反应（MAD）和防御酶（SOD 和 CAT），对氧化应激进行了分析。根据危害商数（HQ）对饮用水进行分析的结果表明，尽管草甘膦的风险较低和中等，但农村人口仍暴露在草甘膦的环境中。相关研究结果表明，必须实施监测/生物监测计划，以防止农村人口受到污染和毒性影响。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.