Disrupted harmony of the skull skeleton: Middle ear resonance in acromegaly

IF 1.6 4区医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2024-06-01 DOI:10.1016/j.ghir.2024.101594

Elif Kaya Çelik , Serap Er , Kemal Keseroğlu , Fatih Öner , Hakan Düğer , Bekir Uçan , Muhammed Kızılgül , Şirin Çetin , Güleser Saylam

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Abstract

Objectives

This study aims to investigate whether the middle ear resonance frequency (RF) is affected in acromegaly, which causes growth in the skull bone.

Methods

Thirty acromegaly patients and 38 volunteers were included in the study. Pure tone average scores and middle ear RF values of the groups that underwent pure tone audiometry, tympanometry, and multifrequency tympanometry tests were compared.

Results

The pure tone mean was 14.95 ± 12.13 in acromegaly patients and 5.70 ± 8.52 in the control group (p:0.18). Sensorineural hearing loss(SNHL) was observed in 16.6% of the patients. The average middle ear RF was calculated as 815 ± 179.05 Hz in patients with acromegaly and 773 ± 127.15 in the control group. (p = 0.0001).

Conclusion

This study is the first to evaluate middle-ear RF in acromegaly patients. Acromegaly-induced changes in soft tissues and bone structures impact middle ear functions. In this patient group, we found an increase in middle ear RF without conductive-type hearing loss and a 16.6% rate of SNHL.

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颅骨骨架的和谐被破坏：肢端肥大症的中耳共鸣

目的本研究旨在探讨肢端肥大症患者的中耳共振频率（RF）是否会受到影响，因为肢端肥大症会导致颅骨增生。结果肢端肥大症患者的纯音平均值为（14.95 ± 12.13），对照组为（5.70 ± 8.52）（P:0.18）。16.6%的患者出现感音神经性听力损失（SNHL）。经计算，肢端肥大症患者的平均中耳射频为 815 ± 179.05 Hz，对照组为 773 ± 127.15 Hz。(结论本研究首次评估了肢端肥大症患者的中耳射频。肢端肥大症引起的软组织和骨结构变化会影响中耳功能。在这组患者中，我们发现中耳射频增加，但无传导型听力损失，SNHL 发生率为 16.6%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.

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