HYPOADIPONECTINEMIA IS ASSOCIATED INSULIN RESISTANCE AND DYSLIPIDEMIA AND HENCE INCREASES CARDIOVASCULAR RISK IN TYPE 2 DIABETES MELLITUS

G. Kanakasabai, N. Saravanan, G Hariprasath.
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Abstract

Background: Cardiovascular disease remains the most common cause of morbidity and mortality in Type 2 Diabetes Mellitus. Insulin Resistance and Dyslipidemia are the important factors contributing to cardiovascular risk in Diabetes. Adiponectin is an adipocytokine involved in the regulation of glucose and lipid metabolism. In the present study we studied the association of Plasma Adiponectin with Insulin Resistance and Lipid prole parameters in Type 2 Diabetes.Materials and Methods: The study included 100 Type 2 Diabetic Subjects and 100 age-matched healthy individuals with no history of Diabetes. The Anthropometric measurements, Fasting and Post prandial plasma glucose, Fasting insulin, Plasma Adiponectin and Lipid prole were measured in these subjects. HOMA- IR formula was used to calculate Insulin Resistance. Results: Fasting and Post prandial plasma glucose, Insulin and HOMA-IR were increased in Type 2 Diabetic Subjects when compared to controls. Plasma Adiponectin was signicantly reduced in Type 2 Diabetic Subjects compared to controls. In Type 2 Diabetic Subjects, Plasma Adiponectin was found signicantly inversely correlated with insulin resistance (r=-0.58, p<0.01), Total cholesterol (r=-0.51, p<0.01), Triglycerides (r=-0.44, p<0.01) and LDL-C levels (r=-0.56, p<0.01). Asignicant Positive correlation was also observed between Plasma Adiponectin and HDL-C level (r=0.37, p<0.01) in Type 2 Diabetic Subjects. Conclusion:Hypoadiponectinemia in Type 2 Diabetes is associated with Insulin Resistance and Dyslipidemia and plays a key role in the development of cardiovascular risk.
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低脂酮血症与胰岛素抵抗和血脂异常有关,因此会增加 2 型糖尿病患者的心血管风险
背景:心血管疾病仍是 2 型糖尿病患者发病和死亡的最常见原因。胰岛素抵抗和血脂异常是导致糖尿病患者心血管疾病风险的重要因素。脂联素是一种脂肪细胞因子,参与葡萄糖和脂质代谢的调节。在本研究中,我们研究了血浆脂肪粘连素与 2 型糖尿病患者胰岛素抵抗和脂质原le 参数的关系:研究对象包括 100 名 2 型糖尿病受试者和 100 名年龄匹配、无糖尿病史的健康人。这些受试者的人体测量指标、空腹和餐后血浆葡萄糖、空腹胰岛素、血浆脂肪连素和血脂原。采用 HOMA- IR 公式计算胰岛素抵抗。结果:与对照组相比,2型糖尿病受试者的空腹和餐后血浆葡萄糖、胰岛素和HOMA-IR均有所增加。与对照组相比,2 型糖尿病受试者的血浆降血脂素显著。在 2 型糖尿病受试者中,发现血浆脂肪连通素与胰岛素抵抗(r=-0.58,p<0.01)、总胆固醇(r=-0.51,p<0.01)、甘油三酯(r=-0.44,p<0.01)和低密度脂蛋白胆固醇水平(r=-0.56,p<0.01)显著成反比。在 2 型糖尿病受试者中还观察到血浆脂肪连接蛋白与高密度脂蛋白胆固醇水平(r=0.37,p<0.01)呈正相关。结论:2 型糖尿病患者的低脂连接蛋白血症与胰岛素抵抗和血脂异常有关,在心血管风险的发展中起着关键作用。
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