α-Chloroketones enabled Rh(III)-catalyzed enantioselective C–H [4+2] annulation of sulfoximines under mild and redox-neutral conditions

Abstract

Taking advantage of facilely available α-chloroketones as C(sp³)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel Cp^xRh(III)-catalyzed enantioselective C–H [4 ​+ ​2] annulation of sulfoximines under mild and redox-neutral conditions to access S-chiral 1,2-benzothiazines. It represents the first example of such C(sp³)-electrophiles enabling enantioselective C–H functionalization.