Somatosensory evoked spikes in normal adults detected by magnetoencephalography

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-05-22 DOI:10.1016/j.clinph.2024.05.006

Makoto Ishida, Yosuke Kakisaka, Kazutaka Jin, Akitake Kanno, Nobukazu Nakasato

{"title":"Somatosensory evoked spikes in normal adults detected by magnetoencephalography","authors":"Makoto Ishida, Yosuke Kakisaka, Kazutaka Jin, Akitake Kanno, Nobukazu Nakasato","doi":"10.1016/j.clinph.2024.05.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Somatosensory evoked spikes (SESs) have been reported only in children aged under 14 years and are considered as an age-dependent phenomenon. However, we detected SESs in adult patients with epilepsy using magnetoencephalography (MEG). The present study investigated whether MEG can detect SESs in normal adults.</p></div><div><h3>Methods</h3><p>Spontaneous MEG was recorded during measurement of somatosensory evoked fields (SEFs) for bilateral electrical median nerve stimuli in 30 healthy adults.</p></div><div><h3>Results</h3><p>Bilateral SESs were observed in 10 adults but none in the other 20 subjects. SESs consisted of one or two peaks, and the first peak latency corresponded to that of the second peak (M2) of SEFs. The first SES peak was identical to the M2 in isofield map pattern, as well as location and orientation of the equivalent current dipole (ECD). M2 ECD strength in the 10 subjects with SESs was larger (p <0.0001) than in 20 without SESs.</p></div><div><h3>Conclusions</h3><p>All-or-nothing detection of bilateral SESs by MEG in normal adults must depend on the signal-to-noise issue of symmetrical SEFs and background brain activity.</p></div><div><h3>Significance</h3><p>Our results further confirm the higher sensitivity of MEG compared to scalp EEG for the detection of focal cortical sources tangential to the scalp such as SESs.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S138824572400155X/pdfft?md5=7ddf1f3a1e7740061a378000cf892c5b&pid=1-s2.0-S138824572400155X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138824572400155X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Somatosensory evoked spikes (SESs) have been reported only in children aged under 14 years and are considered as an age-dependent phenomenon. However, we detected SESs in adult patients with epilepsy using magnetoencephalography (MEG). The present study investigated whether MEG can detect SESs in normal adults.

Methods

Spontaneous MEG was recorded during measurement of somatosensory evoked fields (SEFs) for bilateral electrical median nerve stimuli in 30 healthy adults.

Results

Bilateral SESs were observed in 10 adults but none in the other 20 subjects. SESs consisted of one or two peaks, and the first peak latency corresponded to that of the second peak (M2) of SEFs. The first SES peak was identical to the M2 in isofield map pattern, as well as location and orientation of the equivalent current dipole (ECD). M2 ECD strength in the 10 subjects with SESs was larger (p <0.0001) than in 20 without SESs.

Conclusions

All-or-nothing detection of bilateral SESs by MEG in normal adults must depend on the signal-to-noise issue of symmetrical SEFs and background brain activity.

Significance

Our results further confirm the higher sensitivity of MEG compared to scalp EEG for the detection of focal cortical sources tangential to the scalp such as SESs.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

通过脑磁图检测正常成年人的体感诱发尖峰

目的据报道，只有 14 岁以下的儿童才会出现感觉诱发尖波（SES），而且这种现象与年龄有关。然而，我们利用脑磁图（MEG）在成年癫痫患者中检测到了 SES。本研究调查了脑磁图是否能检测到正常成人的 SES。方法在测量双侧正中神经电刺激的体感诱发电场（SEF）时，记录了 30 名健康成人的自发脑磁图。SES 由一个或两个峰值组成，第一个峰值的潜伏期与 SEF 第二个峰值（M2）的潜伏期一致。第一个 SES 峰在等场图模式、等效电流偶极子（ECD）的位置和方向上与 M2 峰相同。我们的研究结果进一步证实，与头皮脑电图相比，MEG 在检测与头皮相切的局灶性皮质源（如 SES）方面具有更高的灵敏度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.