Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-23 DOI:10.1016/j.bbcan.2024.189121
Zheng Zhang , Zhen Gang Lv , Miao Lu , Haifeng Li , Jiahua Zhou
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Abstract

The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition, the dynamic interaction between nerve and tumor cells in the tumor microenvironment also regulate tumor progression. On the one hand, nerves are passively invaded by tumor cells, that is, perineural invasion (PNI). On the other hand, compared with normal tissues, tumor tissues are subject to more abundant innervation, and nerves can influence tumor progression through regulating tumor proliferation, metastasis and drug resistance. A large number of studies have shown that nerve-tumor crosstalk, including PNI and innervation, is closely related to the prognosis of patients, and contributes to the formation of cancer pain, which significantly deteriorates the quality of life for patients. These findings suggest that nerve-tumor crosstalk represents a potential target for anti-tumor therapies and the management of cancer pain in the future. In this review, we systematically describe the mechanism by which nerve-tumor crosstalk regulates tumorigenesis and progression.

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肿瘤微环境中的神经-肿瘤串扰:从肿瘤的发生、发展到临床意义
自律神经系统(ANS)支配着全身的器官和组织,并维持着各系统之间的功能平衡。进一步的研究表明,自律神经系统的过度激活不仅会破坏体内平衡,还可能促进肿瘤的形成。此外,神经和肿瘤细胞在肿瘤微环境中的动态相互作用也调控着肿瘤的发展。一方面,神经被动地受到肿瘤细胞的侵袭,即神经周围侵袭(PNI)。另一方面,与正常组织相比,肿瘤组织受到更丰富的神经支配,神经可通过调节肿瘤的增殖、转移和耐药性影响肿瘤的进展。大量研究表明,神经-肿瘤串扰(包括 PNI 和神经支配)与患者的预后密切相关,并导致癌痛的形成,从而显著恶化患者的生活质量。这些发现表明,神经-肿瘤串扰是未来抗肿瘤疗法和癌痛治疗的潜在靶点。在这篇综述中,我们系统地阐述了神经-肿瘤串扰调控肿瘤发生和发展的机制。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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