Green synthesis of silver nanoparticles using leaf extract of Woodfordia fruticosa (L.) for potential therapeutic application

IF 2.8 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of chemical technology and biotechnology Pub Date : 2024-05-22 DOI:10.1002/jctb.7681
Debasmita Dubey, Rajesh Kumar Meher, Biswaranjan Pradhan, Sadhni Induar, Biswakanth Kar, Pradeep Kumar Naik, Bikash Chandra Behera
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Abstract

BACKGROUND

Woodfordia fruticosa is a well-known medicinal plant traditionally used for various treatment methods. Green synthesis of silver nanocomposite with woodfordia flower extract is well-investigated. However, the therapeutic potential of Woodfordia fruticosa leaf extract silver nanoparticles against various diseases has yet to be investigated.

RESULTS

Silver nanoparticles synthesized from Woodfordia fruticosa leaf extract (Wf-AgNPs) showed UV spectral peaks at 450 nm. Transmission electron microscope (TEM) images, ranging from 20 to 50 nm, confirm the nanosynthesis. The average particle size of 39.63 nm with a zeta potential distribution value 17.0 was observed. Fourier transform infrared peaks ranging from 2942to 669 cm−1 confirm the amines, amides, carboxylic, aldehyde, alkane, phenolic and aliphatic bromo compounds involved in the synthesis of AgNPs. Wf-AgNPs showed higher antioxidant activity compared to the ascorbic acid and BHT. The phenolic and flavonoid content was 141.66 ± 8.50 mg GAE/100 g dry weight and 191.66 ± 5.6 mg quercetin equivalent/100 g dry weight, respectively. Wf-AgNPs showed a strong inverse relationship between the dose and viability of the cancer cells. The antibacterial properties of Wf-AgNPs were confirmed through the bacteria's SEM images. Increased wound healing potential, re-epithelization and elevation of the tensile strength of the infected skin tissue were observed after applying synthesized Wf-AgNPs.

CONCLUSION

Various phytochemicals in the synthesized nanoparticles confer antimicrobial, antioxidant, anticancer and wound-curing potentiality to the Wf-AgNPs. © 2024 Society of Chemical Industry (SCI).

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利用木芙蓉(L.)叶提取物绿色合成银纳米粒子的潜在治疗应用
背景木芙蓉是一种著名的药用植物,传统上用于各种治疗方法。用木芙蓉花提取物绿色合成银纳米复合材料的研究进展顺利。结果用木芙蓉叶提取物合成的纳米银颗粒(Wf-AgNPs)在 450 纳米波长处显示出紫外光谱峰。透射电子显微镜(TEM)图像在 20 至 50 纳米之间,证实了纳米合成。观察到平均粒径为 39.63 nm,zeta 电位分布值为 17.0。从 2942 到 669 cm-1 的傅立叶变换红外峰值证实,胺、酰胺、羧酸、醛、烷、酚和脂肪族溴化合物参与了 AgNPs 的合成。与抗坏血酸和 BHT 相比,Wf-AgNPs 表现出更高的抗氧化活性。酚类和类黄酮含量分别为 141.66 ± 8.50 毫克 GAE/100 克干重和 191.66 ± 5.6 毫克槲皮素当量/100 克干重。Wf-AgNPs 的剂量与癌细胞的存活率之间呈强烈的反比关系。细菌的扫描电镜图像证实了 Wf-AgNPs 的抗菌特性。结论合成纳米粒子中的各种植物化学物质赋予了 Wf-AgNPs 抗菌、抗氧化、抗癌和伤口愈合的潜力。© 2024 化学工业学会(SCI)。
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来源期刊
CiteScore
7.00
自引率
5.90%
发文量
268
审稿时长
1.7 months
期刊介绍: Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.
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Issue Information Adsorption behavior of graphite‐like walnut shell biochar modified with ammonia for ciprofloxacin in aqueous solution Eco‐friendly approaches for synthesis of indolyl 1H‐pyrroles using rice‐husk‐derived carbonaceous sulfonation as the green catalyst Impact of neutrophil‐activating protein conservation on diagnostic tests and vaccine design Issue Information
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