Comparing the effects of Bone+B® xenograft and InterOss® xenograft bone material on rabbit calvaria bone defect regeneration

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-05-26 DOI:10.1002/cre2.875

Afshin Yadegari Naini, Sepehr Kobravi, Aida Jafari, Mohammadhassan Lotfalizadeh, Narges Lotfalizadeh, Sareh Farhadi

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Abstract

Background

The bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore, these implants may be a good option for enhancing and stabilizing maxillary sinuses. The purpose of this study was to compare two xenografts, Bone⁺B® and InterOss®, for the reconstruction of rabbit calvaria defects.

Methods and Materials

The study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8-millimeter defects. A control group was used, as well as two treatment groups utilizing Bone⁺B® Grafts and InterOss® Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.

Results

With the application of Bone⁺B® graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (±5.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (±3.65). Using InterOss® grafts, bone formation was 61% to 75%, the mean was 65.83% (±4.75), and the remaining material was 9% to 18%, with a mean of 13.17% (±3.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (±6.11). InterOss® had lower inflammation levels than other groups, but the difference was not statistically significant (p > .05).

Conclusion

InterOss® bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone⁺B® improves healing and bone quality, thus making it an alternative to InterOss®.

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比较 Bone+B® 异种移植骨材料和 InterOss® 异种移植骨材料对兔小腿骨缺损再生的影响。

背景：骨再生疗法常用于种植体骨支持不足的患者，尤其是拔牙后的患者。从动物组织中提取的异种移植物是一种有效的骨重建选择，它能抵抗吸收，传播疾病的风险也很低。因此，这些种植体可能是增强和稳定上颌窦的良好选择。本研究的目的是比较 Bone+B® 和 InterOss® 两种异种移植物在兔腭窦缺损重建中的应用：这项研究涉及七只雄性新西兰白兔。在手术过程中，通过在小腿中线两侧创建三个 8 毫米的缺损，共创建了 21 个点。分为对照组以及使用 Bone+B® 人工骨和 InterOss® 人工骨的两个治疗组。3 个月后，兔子被安乐死，然后进行病理评估。使用 Adobe Photoshop CS 8.0 和 SPSS 24.0 版对这些样本进行分析，重点关注骨形成、异种移植剩余材料和炎症水平：使用 Bone+B® 移植物时，骨形成率为 32% 至 45%，平均值为 37.80%（±5.63），剩余材料率为 28% 至 37%，平均值为 32.60%（±3.65）。使用 InterOss® 移植物时，骨形成率为 61% 至 75%，平均为 65.83%（±4.75），剩余材料为 9% 至 18%，平均为 13.17%（±3.06）。对照组的骨形成率为 10%-25%，平均为 17.17%（±6.11）。InterOss®骨粉的炎症水平低于其他组，但差异无统计学意义（P > .05）：结论：InterOss® 骨粉是颌面手术和骨重建的最佳选择。结论：InterOss® 骨粉是颌面手术和骨重建的最佳选择，因为它能形成更多的骨，减少剩余材料，降低炎症水平。与对照组相比，Bone+B® 可改善愈合和骨质，因此可作为 InterOss® 的替代品。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.