Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-05-26 DOI:10.1002/cre2.887

Morad Hedayatipanah, Leila Gholami, Abbas Farmany, Mohammad Yusef Alikhani, Amirarsalan Hooshyarfard, Fahime Sadat Hashemiyan

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Abstract

Objective

This study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of Porphyromonas gingivalis biofilms.

Material and Methods

AgNPs were synthesized from propolis, and their inhibitory effect on P. gingivalis biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose-dependent antibacterial activity.

Results

The results of this study indicated that AgNPs exhibited an inhibitory effect on P. gingivalis biofilm formation. The antibacterial activity of AgNPs was dose-dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti-biofilm formation activity.

Conclusion

The results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on P. gingivalis biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.

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银纳米粒子的绿色合成及其对牙龈卟啉单胞菌生物膜形成影响的评估。

研究目的本研究旨在评估由蜂胶合成的银纳米粒子（AgNPs）对牙龈卟啉单胞菌生物膜形成的影响：从蜂胶中合成 AgNPs，并评估其对牙龈卟啉单胞菌生物膜形成的抑制作用。测试了不同浓度的 AgNPs（0.1%、0.3% 和 0.5%），以确定其抗菌活性的剂量依赖性：研究结果表明，AgNPs 对牙龈脓胞生物膜的形成具有抑制作用。AgNPs 的抗菌活性呈剂量依赖性，浓度为 0.1%、0.3% 和 0.5% 时均有效。值得注意的是，0.5% 的浓度具有最显著的抗生物膜形成活性：本研究结果表明，由蜂胶合成的 AgNPs 有潜力成为提高牙周治疗效果的有效选择。AgNPs对牙龈脓胞生物膜形成的抑制作用凸显了其作为替代抗菌剂治疗牙周疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.