A Systematic Review of Cost-Effectiveness Analyses Examining Treatments for Cachexia Syndrome.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-05-27 DOI:10.1080/01635581.2024.2353939
Safeer Khan, Safeer Ahmad Javid, Sabi Ur Rehman, Yasmeen Akhtar, Muhammad Amir Khan
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Abstract

Objectives: This systematic review aims to critically evaluate and synthesize the economic outcomes of various therapeutic strategies employed to manage cachexia patients.

Methods: A comprehensive search for randomized controlled trials and observational studies was conducted from January 1, 2000 to December 31, 2023, using PubMed, Google Scholar, Clinical Trials Registry, Cochrane Central Register of Controlled Trials, British Medical Journal, National Health Service Economic Evaluation Database, and ScienceDirect, following PRISMA guidelines. We assessed the quality of the included studies using the Consolidated Health Economic Evaluation Reporting Standards reporting guidelines.

Results: We identified six high to medium quality economic evaluations in four countries, focusing on cancer, chronic obstructive pulmonary disease, and HIV/AIDS-associated cachexia. The results indicate that combination management strategies, specifically the use of nutritional supplements and exercise, are more cost-effective than usual care for cachexia syndrome. Additionally, two studies showed that dietary supplements alone were more cost-effective than usual care, and pharmacotherapy alone was more cost-effective than a placebo.

Conclusion: Combining several strategies, such as nutritional supplements and exercise, may be the most economically efficient method for managing cachexia compared to usual care or single treatment approaches. However, the restricted and diverse characteristics of the current research hinder the definitive conclusions.

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对检查achexia 综合征治疗方法的成本效益分析的系统性回顾。
目的本系统综述旨在批判性地评估和综合处理恶病质患者的各种治疗策略的经济效益:从 2000 年 1 月 1 日至 2023 年 12 月 31 日,我们按照 PRISMA 指南使用 PubMed、Google Scholar、临床试验注册中心、Cochrane 对照试验中央注册中心、《英国医学杂志》、国家卫生服务经济评估数据库和 ScienceDirect 对随机对照试验和观察性研究进行了全面检索。我们采用《卫生经济评价综合报告标准》报告指南评估了纳入研究的质量:结果:我们在 4 个国家发现了 6 项高到中等质量的经济评估,重点关注癌症、慢性阻塞性肺病和艾滋病毒/艾滋病相关恶病质。结果表明,对于恶病质综合征,综合管理策略,特别是使用营养补充剂和锻炼,比常规护理更具成本效益。此外,两项研究表明,单独使用膳食补充剂比常规护理更具成本效益,而单独使用药物疗法比安慰剂更具成本效益:结论:与常规护理或单一治疗方法相比,将营养补充剂和运动等几种策略结合起来可能是控制恶病质最经济有效的方法。然而,当前研究的局限性和多样性特征阻碍了最终结论的得出。
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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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