Assessment for Diabetic Neuropathy: Treatment and Neurobiological Perspective.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-05-24 DOI:10.2174/0115733998290606240521113832
Bhanupriya Bhrigu, Shikha Sharma, Nitin Kumar, Bimal Krishna Banik
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Abstract

Diabetic neuropathy, also known as diabetic peripheral sensorimotor neuropathy (DPN), is a consequential complexity of diabetes, alongside diabetic nephropathy, diabetic cardiomyopathy, and diabetic retinopathy. It is characterized by signs and symptoms of peripheral nerve damage in diabetes patients after ruling out other causes. Approximately 20% of people with diabetes are affected by this painful and severe condition. The development of diabetic neuropathy is influenced by factors such as impaired blood flow to the peripheral nerves and metabolic issues, including increased polyol pathway activation, myo-inositol loss, and nonenzymatic glycation. The present review article provides a brief overview of the pathological changes in diabetic neuropathy and the mechanisms and types of DPN. Various diagnostic tests and biomarkers are available to assess nerve damage and its severity. Pharmacotherapy for neuropathic pain in diabetic neuropathy is complex. This review will explore current treatment options and potential future developments to improve the quality of life for patients suffering from diabetic neuropathy.

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糖尿病神经病变评估:治疗和神经生物学视角。
糖尿病神经病变又称糖尿病周围感觉运动神经病变(DPN),是糖尿病的一种并发症,与糖尿病肾病、糖尿病心肌病和糖尿病视网膜病变并称为糖尿病的三大并发症。其特征是糖尿病患者在排除其他病因后出现周围神经损伤的症状和体征。约有 20% 的糖尿病患者会受到这种痛苦而严重的病症的影响。糖尿病神经病变的发生受多种因素的影响,如周围神经血流受损和代谢问题,包括多元醇通路激活增加、肌醇损失和非酶糖化。本综述文章简要概述了糖尿病神经病变的病理变化以及 DPN 的机制和类型。目前有多种诊断测试和生物标志物可用于评估神经损伤及其严重程度。糖尿病神经病变中神经病理性疼痛的药物治疗非常复杂。本综述将探讨当前的治疗方案和未来的潜在发展,以改善糖尿病神经病变患者的生活质量。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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