Association of PM2.5 chemical constituents with general, abdominal and visceral obesity and mediation roles of physical activity

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Sciences Europe Pub Date : 2024-05-27 DOI:10.1186/s12302-024-00935-4
Tingting Ye, Ying Shao, Changwei Cai, Yuchen Li, Bin Yu, Xu Qiao, Chuanteng Feng, Peng Jia, Shujuan Yang
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Abstract

Background

The association between exposure to PM2.5 chemical constituents and obesity remains to be elucidated, as most studies have used a single measure of obesity. This study aimed to investigate the associations of exposure to PM2.5 chemical constituents with general, abdominal, and visceral obesity, and the mediation effect of physical activity (PA) in the associations.

Methods

Based on a total of 49,819 adults from the baseline of the Yunnan Behavior and Disease Surveillance cohort (YBDS) in southern China in 2021, we used multiple linear regression, weighted quantile sum regression, and quantile regression to estimate independent and joint effects of PM2.5 chemical constituents on elevated BMI, waist circumference (WC) and visceral adiposity index (VAI) and whether these effects changed in quantiles. Mediation analysis was used to examine whether physical activity acts as a mediator in these pathways.

Results

Per IQR μg/m3 increase in all PM2.5 chemical constituents was significantly associated with the elevated BMI (β [95% CI]: 0.170 [0.127, 0.214]), WC (0.316 [0.217, 0.415]) and VAI (0.102 [0.075, 0.129]), with the largest weights from OM (53.89, 81.67, and 89.82%, respectively). The effects of PM2.5 chemical constituents on obesity showed an overall upward trend from quantiles 1–4 of BMI, WC, and VAI, especially with a rapid upward trend from the sixth decile of VAI. Reduced PA mediated 3.16, 7.08, and 3.78% of the associations between PM2.5 chemical constituents and elevated BMI, WC, and VAI, respectively.

Conclusions

Exposure to PM2.5 chemical constituents, especially OM, was significantly associated with increased risks for obesity in adults. The effects of associations increased with obesity severity, with PA playing a mediation role.

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PM2.5 化学成分与全身肥胖、腹部肥胖和内脏肥胖的关系以及体育锻炼的调解作用
背景 PM2.5化学成分暴露与肥胖之间的关系仍有待阐明,因为大多数研究使用的是单一的肥胖测量方法。本研究旨在探讨暴露于PM2.5化学成分与全身肥胖、腹部肥胖和内脏肥胖之间的关系,以及体育锻炼(PA)在这些关系中的中介作用。方法基于2021年中国南方云南行为与疾病监测队列(YBDS)基线的49 819名成年人,我们使用多元线性回归、加权量子和回归和量子回归来估计PM2.5化学成分对体重指数(BMI)、腰围(WC)和内脏脂肪指数(VAI)升高的独立效应和联合效应,以及这些效应是否随量子位数的变化而变化。结果 所有 PM2.5 化学成分中每 IQR μg/m3 的增加与 BMI 升高显著相关(β [95% CI]: 0.170[0.127,0.214])、WC(0.316[0.217,0.415])和 VAI(0.102[0.075,0.129])的升高明显相关,其中来自 OM 的权重最大(分别为 53.89%、81.67%和 89.82%)。PM2.5化学成分对肥胖的影响从BMI、WC和VAI的1-4分位数开始呈总体上升趋势,尤其是从VAI的第六个十分位数开始呈快速上升趋势。在PM2.5化学成分与BMI、WC和VAI升高的关联中,PA的减少分别起到了3.16%、7.08%和3.78%的中介作用。相关影响随着肥胖严重程度的增加而增加,而PA则起着调解作用。
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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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