Exploring pathogenic pathways in carpal tunnel syndrome: sterile inflammation and oxidative stress.

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-05-29 eCollection Date: 2024-05-01 DOI:10.1515/jbcpp-2024-0004
Mohd Sajid Arshad, Bhawna Mattoo, Iqbal Alam
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Abstract

Objectives: The main objective of the current study was to find the association between oxidative stress, inflammatory markers, and electrophysiological profile with symptom severity in patients of carpal tunnel syndrome (CTS).

Methods: Thirty-two carpal tunnel syndrome patients and 32 controls were included in the study. Boston CTS questionnaire along with plasma oxidative stress markers including superoxide dismutase, malondialdehyde, and nitric oxide and inflammatory markers including IL-6 and TNF-α were compared with the electrophysiological parameters derived from nerve conduction studies. Statistical significance of the levels between groups was calculated using unpaired-t test after checking for normality with D'Agostino & Pearson omnibus normality test.

Results: We found that the median nerve conduction velocity was prolonged, amplitude was decreased, while the levels of oxidative stress markers like malondialdehyde (MDA), superoxidase dismutase (SOD), and nitric oxide (NO) were increased in CTS patients compared to controls. Inflammatory markers like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were also increased in CTS patients. We found that plasma SOD and TNF-α correlated well with the median motor amplitude. There was no other significant correlation between oxidative stress markers and inflammatory markers with nerve conduction studies or disease severity. Patients with mild disease also showed lesser levels of SOD, NO, IL-6, and TNF-α markers than patients with severe disease.

Conclusions: CTS is probably a disease of sterile inflammation and disbalance of oxidative stress, with higher inflammatory and oxidative stress markers pointing to a more severe disease.

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探索腕管综合征的致病途径:无菌性炎症和氧化应激。
研究目的本研究的主要目的是发现氧化应激、炎症标记物和电生理特征与腕管综合征(CTS)患者症状严重程度之间的关联:研究对象包括 32 名腕管综合征患者和 32 名对照组患者。将波士顿 CTS 问卷、血浆氧化应激标记物(包括超氧化物歧化酶、丙二醛和一氧化氮)以及炎症标记物(包括 IL-6 和 TNF-α)与神经传导研究得出的电生理参数进行比较。用 D'Agostino & Pearson 综合正态性检验检查正态性后,用非配对 t 检验计算组间水平的统计学意义:我们发现,与对照组相比,CTS 患者的正中神经传导速度延长,振幅降低,而丙二醛 (MDA)、超氧化物歧化酶 (SOD) 和一氧化氮 (NO) 等氧化应激标记物的水平升高。白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)等炎症指标在 CTS 患者中也有所增加。我们发现血浆 SOD 和 TNF-α 与中位运动振幅密切相关。氧化应激标记物和炎症标记物与神经传导研究或疾病严重程度之间没有其他明显的相关性。轻度患者的SOD、NO、IL-6和TNF-α标记物水平也低于重度患者:结论:CTS可能是一种无菌性炎症和氧化应激失衡的疾病,炎症和氧化应激标志物越高,说明病情越严重。
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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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