Journal of Basic and Clinical Physiology and Pharmacology最新文献

Objectives: To compare heart rate variability (HRV) among adult Hypertensive and Normotensive subjects in supine position.

Methods: It was an analytical cross sectional study conducted on two study groups. The cases (n=60) comprised of outpatients (males and females in the age group 20-50 yrs) attending the Medicine OPD of Medical Collage, Kolkata, who were newly diagnosed as cases of hypertension according to JNC seven criteria while the control group (n=50) comprised of age and sex-matched adult normotensive subjects, who were non-smokers, non-alcoholics and were not suffering from any major cardiac, neurological or chronic illnesses. HRV profiling through short-term (5 min) ECG recording of each subject was carried out in the supine position with the help of a digital ECG recording machine (RMS-Polyrite D), with a sampling rate of 256 Hz. From the data so collected, various HRV parameters - both time domain (SDNN, RMSSD, NN50 and pNN50) and frequency domain (VLF, LF and HF) were calculated. Analysis of these parameters revealed the pattern of autonomic influence (sympathetic or parasympathetic predominance) prevalent among the subjects of the study and control groups.

Results: An overall reduction of the time domain parameters SDNN and RMSSD (considered more as markers of sympathetic activity) and frequency domain parameters (total power, LF and HF, all expressed in ms²), which are markers of parasympathetic activity, was noted among the hypertensive subjects. However, the reduction in frequency domain parameters was much more (highly significantly) than that of time domain parameters. Also, both age and hypertension had significant independent effects on HRV but their 3-way interaction was found to be statistically insignificant.

Conclusions: The findings of the study thus points towards an autonomic dysregulation (characterized by decreased vagal activity and increased sympathetic activity), as an underlying basis (i.e. an important factor, among others) for hypertension.

Objectives: Heart failure is a cardiovascular disease with a high incidence in the world and Indonesia as well. This disease must get serious attention because it results in high mortality rates and has a broad and long-term impact on patients with heart failure. The high recurrence rate, rehospitalization, and patients' poor quality of life are influenced, one of them, by the self-care behavior of patients, considering that heart failure is a progressive and chronic disease. In practice, implementation of self-care behaviors in people living with heart failure is poor. This study analyzes the factors influencing self-care for heart failure patients.

Methods: This is a cross-sectional study that involved 100 heart failure patients taken from August to October 2020. Self-care was measured using the Self-Care of Heart Failure Index (SCHFI) questionnaire. The chi-square statistical test determines the relationship between the factors that influence self-care.

Results: The results showed that there was a significant relationship between education (p 0.00), marital status (p 0.005), occupation (p 0.00), NYHA class (p 0.00), and patient age (p 0.01) with self-care maintenance. There was no relationship between gender (p 0.30), comorbidity (p 0.21), and duration of heart failure (p 0.11).

Conlusions: Education, marital status, occupation, NYHA class, and age significantly influence self-care in heart failure patients, while gender, comorbidity, and disease duration do not. Targeted interventions are needed to improve self-care and reduce rehospitalization.

Objectives: A well-structured, regular, and programmed physical exercise regimen is believed to be an effective physiological modulator for preventing the dysfunction of myonectin and visfatin secretion. Therefore, this study aims to analyze the physiological regulation of moderate-intensity programmed exercise in improving myonectin and visfatin biomarkers in obese women.

Methods: The study involved 30 physically healthy obese women, nonathletes, selected based on predetermined criteria, who voluntarily agreed to participate. They were then divided into two groups: a control group (CRT; n=15) and a programmed exercise group (ART; n=15). The exercise program lasted for 8 weeks, with a frequency of 5 times per week at moderate intensity. Metabolic performance was analyzed using the myonectin and visfatin biomarkers with the Sandwich-ELISA method. Data analysis was conducted using parametric paired sample t-tests and independent sample t-tests at a 5 % significance level.

Results: The study results showed a significant increase in myonectin secretion and a decrease in visfatin secretion (p≤0.05) after 8 weeks of programmed exercise, demonstrated by an increase in myonectin of 97.85 pg/mL and a decrease in visfatin of 0.05 ng/mL. Conversely, in the control group, myonectin decreased by 3.04 pg/mL, and visfatin increased by 0.03 ng/mL.

Conclusions: These findings confirm that an 8-week programmed exercise regimen can improve the secretion of myonectin and visfatin biomarkers, thereby enhancing metabolic performance in obese women. Thus, myonectin and visfatin biomarkers induced by programmed exercise serve as modulators for enhancing metabolic performance in obese women.

Nephropathy and nephrotoxicity are significant causes of renal impairment, with both conditions contributing to a substantial global healthcare burden. Nephropathy encompasses a range of kidney diseases, including glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, and polycystic kidney disease, each with distinct pathophysiological mechanisms and clinical manifestations. Nephrotoxicity, often induced by environmental toxins or medications, can lead to acute kidney injury (AKI) or chronic kidney disease (CKD) if not properly managed. Understanding the underlying processes and risk factors for kidney damage is crucial to preventing and treating these conditions effectively. However, while considerable research exists on each of these topics, there remains a gap in integrated knowledge regarding the diverse pathophysiological pathways, the role of early detection, and the optimal management strategies for nephropathy and nephrotoxicity. While substantial research has been conducted on nephropathy and nephrotoxicity, there remains a year gap in fully understanding the diverse mechanisms of kidney damage across different etiologies and their long-term implications for renal health. This work aimed to fill this gap by synthesizing current research on the pathophysiology, clinical manifestations, and treatment approaches for both nephropathy and nephrotoxicity. Major findings highlight the importance of early detection through biomarkers, the need for vigilant monitoring of renal function, and the role of avoiding nephrotoxic agents in both medical and environmental contexts. The paper also emphasizes the critical role of individualized treatment approaches, including the careful use of medications to prevent drug-induced nephropathy.

Objectives: Type II diabetes mellitus (T2DM) is regarded as a serious illness characterized by high levels of blood sugar due to insulin resistance or insufficient insulin production. T2DM affects millions of people worldwide and is the primary reason for morbidity and mortality. Thus, it is essential to analyze the effect of T2DM on patients. Even though prevailing research has strived to identify the impact of T2DM on several ailments like cardiovascular diseases, neuropathy, retinopathy, and nephropathy. It has disregarded few aspects like pulmonary function, duration of diabetes, and glycemic status. The present study investigates the effect of T2DM on pulmonary function in relation to glycaemia status and duration of diabetes.

Methods: The cross-sectional research is performed on a total of 140 patients with T2DM from the Medical Department. Further, the congregated sample is investigated using SPSS software. The relevant statistical methods are utilized to analyze the research results. The ANOVA analysis reveals the impact of T2DM on pulmonary function; further, the correlation analysis unveils the association among glycemic status, pulmonary function of patients, and duration of diabetes with T2DM.

Results: The outcomes of the research will contribute to revealing the impact of T2DM on pulmonary function in relation to glycemic status and diabetes duration.

Conclusions: The outcomes offer valuable insights into the lung function of patients with T2DM and help in prior treatment for enhancing the pulmonary health. Finally, the proposed research will aid healthcare professionals in better management of T2DM in patients and its related complications.

Objectives: Numerous studies show that the adipokines play a role in on the thyroid axis. The aim of this study was the evaluation of serum level of CTRP-3 and CTRP-6 as a member of the adipokines family in patients with Hashimoto's.

Methods: The levels of CTRP-3 and CTRP-6 were evaluated with enzyme-linked immunosorbent assay in 70 subjects (35 newly diagnosed Hashimoto's thyroiditis and 35 healthy subjects). Their relationship with the thyroid hormone and some biochemical factors was analyzed.

Results: The levels of CTRP3 and CTRP6 in patients with Hashimoto's disease were higher than those in the control group (p<0.05). There was a significant positive correlation between CTRP3 and TSH levels (r=0.286 and p=0.017). There was a significant relationship between CTRP3 and Fasting Blood Sugar (r=0.249 and p=0.038). There was a significant inverse negative correlation between CTRP6 levels and T3 (r=-0.269 and p=0.024), and T4 (r=-0.272 and p=0.023). Moreover, there was a significant positive correlation between CTRP6 serum levels and TSH serum levels (r=0.397 and p=0.001). There was a significant positive correlation between CTRP6 levels and Cholesterol (r=0.351 and p=0.003), and LDL (r=-0.244 and p=0.042).

Conclusions: Finally, our results demonstrated that serum levels of CTRP3 and CTRP6 are higher in patients with Hashimoto's compared to the control group and probably play a role in the pathogenesis of Hashimoto's thyroiditis.

Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder marked by repeated episodes of partial or complete upper airway obstruction during sleep, which leads to intermittent hypoxia and fragmented sleep. These disruptions negatively impact cardiovascular health, metabolic function, and overall quality of life. Obesity is a major modifiable risk factor for OSA, as it contributes to both anatomical and physiological mechanisms that increase the likelihood of airway collapse during sleep. While continuous positive airway pressure (CPAP) therapy remains the gold standard for OSA treatment, its limitations - particularly issues with patient adherence - underscore the need for alternative or adjunct therapeutic options. One such option is the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which are widely recognized for their ability to reduce body weight and improve metabolic health. Emerging evidence suggests that GLP-1 RAs may offer therapeutic benefits in managing OSA, particularly by addressing obesity, a key contributor to the condition. This narrative review seeks to explore the role of GLP-1 RAs in the treatment of OSA, evaluating their efficacy in reducing OSA severity and discussing their broader clinical implications for future research and practice.

Introduction: Metabolic-Associated Steatohepatitis-Related Liver Disease (MASLD) and, its progressive form, Metabolic-Associated Steatohepatitis (MASH) pose significant global health challenges. Current therapeutic strategies targeting metabolic abnormalities have shown promise but lack specificity for the liver. Thyroid hormones, particularly thyroid hormone receptor beta (THR-β) agonists like resmetirom, offer a targeted approach to liver-related pathways.

Content: A network meta-analysis (NMA) comparing different doses of resmetirom to placebo for MASLD and MASH was conducted. PubMed, Scopus, Cochrane, and Web of Science were searched for relevant randomized controlled trials (RCTs). Efficacy outcomes included histological, radiological, and biochemical parameters, while safety outcomes comprised adverse events and treatment discontinuation.

Summary: Resmetirom demonstrated dose-dependent efficacy in histological and radiological assessments, with the 100 mg dose showing superior MASH resolution and hepatic fat reduction. Biochemical markers indicated improved liver function with resmetirom treatment. However, adverse events, particularly diarrhea and nausea, were more prevalent in the resmetirom group, leading to higher treatment discontinuation rates.

Outlook: Resmetirom shows promise as a therapeutic option for MASLD and MASH management, with significant improvements in liver health parameters. However, safety concerns warrant careful monitoring in clinical practice. Further research is needed to optimize its long-term safety and efficacy.

Objectives: Acute myocardial infarction is a critical medical condition that poses a significant risk to life. It is distinguished by the abrupt cessation of blood flow to a specific segment of the cardiac muscle. Acute myocardial infarction accounts for more than 15 % of global mortality annually.

Methods and results: A total of 433 young patients admitted with acute coronary syndrome - myocardial infarction underwent thrombolysis with fibrin specific agents followed by underwent diagnostic coronary angiogram between 01.09.2021 and 31.10.2022. The odds ratio showed a value of 1.973, which is much higher than the individuals with diabetes (0.306). Young individuals (25.9 %) with hypertension have a greater chance of recovery by thrombolysis.

Conclusions: The factors that contribute for the myocardial infarction should be recognized and addressed. Recognizing and addressing these risk factors through education, lifestyle modifications, and early intervention are crucial for preventing myocardial infarction and promoting good health.