Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-25 DOI:10.1016/j.bbcan.2024.189124
M. Kciuk , A. Gielecińska , Ż. Kałuzińska-Kołat , E.B. Yahya , R. Kontek
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Abstract

Apoptosis has traditionally been regarded as the desired cell death pathway activated by chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent discoveries of alternative cell death pathways have paved the way for immune-stimulatory treatment approaches in cancer. Ferroptosis (dependent on iron) and cuproptosis (dependent on copper) hold promise for selective cancer cell targeting and overcoming drug resistance. Copper ionophores and iron-bearing nano-drugs show potential for clinical therapy as single agents and as adjuvant treatments. Here we review up-to-date evidence for the involvement of metal ion-dependent cell death pathways in the cytotoxicity of classical chemotherapeutic agents (alkylating agents, topoisomerase inhibitors, antimetabolites, and mitotic spindle inhibitors) and their combinations with cuproptosis and ferroptosis inducers, indicating the prospects, advantages, and obstacles of their use.

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铁凋亡和铜凋亡:传统化疗激活的金属依赖性细胞死亡途径--对癌症治疗的意义?
由于细胞凋亡具有可控性和非炎症性,传统上一直被认为是化疗药物激活的理想细胞死亡途径。然而,最近发现的替代细胞死亡途径为癌症免疫刺激治疗方法铺平了道路。铁跃迁(依赖于铁)和铜跃迁(依赖于铜)为选择性靶向癌细胞和克服耐药性带来了希望。铜离子载体和含铁纳米药物作为单药和辅助疗法在临床治疗中显示出潜力。在此,我们回顾了金属离子依赖性细胞死亡途径参与经典化疗药物(烷化剂、拓扑异构酶抑制剂、抗代谢药物和有丝分裂纺锤体抑制剂)细胞毒性的最新证据,以及它们与铜氧化酶和铁氧化酶诱导剂的组合,并指出了它们的使用前景、优势和障碍。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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