A Patent Review on the Use of Cyclodextrin Inclusion Complexes to Enhance Physicochemical and Pharmacological Properties in Antidepressant Drugs.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01

José Adão Carvalho Nascimento Júnior, Luiza Abrahão Frank, Alcimary Bispo Santos, Anamaria Mendonça Santos, Tatianny de Araújo Andrade, Paula Dos Passos Menezes, Renata Vidor Contri, Mairim Russo Serafini

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Abstract

Major depressive disorder is considered one of the most common and prevalent diseases worldwide, affecting children, adults, and the elderly. Currently, several antidepressant drugs are available on the market, but the low adherence of patients due to the slow therapeutic response is a problem to be solved. In this way, cyclodextrins become an alternative to circumvent the limitations and improve the physicochemical and pharmacological properties of this class of drugs. Thus, the objective of this work is to carry out a current review of patents associating antidepressant drugs and cyclodextrins. The patent search was performed in two patent databases, the World Intellectual Property Organization and the European Patent Office using terms in the title and abstract fields and the international patent classification code for antidepressant drugs. In the end, 27 patent documents were selected and divided into three classifications, physical-chemical characterization study, pre-clinical in vivo trials, and clinical trials. The scientific evidence found in the patents considers the use of cyclodextrins as an important alternative to improve the therapeutic and physicochemical properties of antidepressant drugs, among the main improved properties are, solubility, stability, masking taste and odor, bioavailability.

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关于使用环糊精包合物增强抗抑郁药物理化和药理特性的专利综述。

重度抑郁症被认为是全球最常见、最普遍的疾病之一，影响着儿童、成人和老年人。目前，市场上有多种抗抑郁药物可供选择，但由于治疗反应缓慢，患者的依从性较低，这是一个亟待解决的问题。因此，环糊精成为了一种替代品，可以规避这类药物的局限性，并改善其理化和药理特性。因此，这项工作的目的是对与抗抑郁药物和环糊精相关的专利进行审查。专利检索是在世界知识产权组织和欧洲专利局两个专利数据库中进行的，检索时使用了标题和摘要字段中的术语以及抗抑郁药物的国际专利分类代码。最终选择了 27 份专利文件，并将其分为三类：物理化学特征研究、临床前体内试验和临床试验。专利中发现的科学证据认为，使用环糊精是改善抗抑郁药物治疗和理化特性的重要替代品，其中主要改善的特性包括：溶解性、稳定性、掩盖味道和气味、生物利用度。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.