Reduction of MRONJ risk after exodontia by virtue of ozone infiltration: A randomized clinical trial.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI:10.1111/odi.15006

Olga Di Fede, Gaetano La Mantia, Carmine Del Gaizo, Rodolfo Mauceri, Domenica Matranga, Giuseppina Campisi

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Abstract

Introduction: Exodontia is commonly considered as a risk factor for the development of medication-related osteonecrosis of the jaw (MRONJ) in individuals exposed to bone modifying agents. This study was aimed at assessing the efficiency and safety of a gaseous oxygen-ozone mixture as an adjuvant to a standard exodontia to reduce the risk of MRONJ development.

Methods: A randomized, open-label, phase II, single-center clinical trial involving 117 patients at risk of MRONJ was conducted. The study protocol tested injections of an oxygen-ozone mixture in the post-extraction site. Participants were randomly assigned to two groups: oxygen-ozone therapy, and standard tooth extraction protocol. Post-extraction wound healing was assessed using the Inflammatory Proliferative Remodeling (IPR) Wound Healing Scale.

Results: The oxygen-ozone therapy group exhibited a significant improvement in wound healing post-extraction during the inflammatory and proliferative phases, as indicated by the IPR scale scores at 3-5 days (p = 0.006) and 14 days (p < 0.001) respectively.

Conclusion: Oxygen-ozone therapy shows promise in improving post-extraction healing in patients at risk of MRONJ. Future studies with larger sample sizes and multicenter collaborations are recommended to confirm the validity of these findings and explore the long-term efficacy of ozone therapy.

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通过臭氧浸润降低牙齿外翻后的 MRONJ 风险：随机临床试验

导言：外固定通常被认为是接触骨改良剂的患者发生药物相关性颌骨坏死（MRONJ）的风险因素。本研究旨在评估气态氧-臭氧混合物作为标准外固定辅助剂的有效性和安全性，以降低发生 MRONJ 的风险：进行了一项随机、开放标签、II 期、单中心临床试验，涉及 117 名有 MRONJ 风险的患者。研究方案测试了在拔牙后部位注射氧-臭氧混合物。参与者被随机分配到两组：氧气-臭氧疗法组和标准拔牙方案组。拔牙后伤口愈合情况采用炎症增生重塑（IPR）伤口愈合量表进行评估：结果：从 3-5 天（p = 0.006）和 14 天（p 结论：氧-臭氧疗法组在拔牙后的炎症期和增殖期的伤口愈合有明显改善：氧-臭氧疗法有望改善有 MRONJ 风险的患者拔牙后的愈合。建议今后开展样本量更大和多中心合作的研究，以证实这些发现的有效性，并探索臭氧疗法的长期疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.