An IL-10 homologue encoded by human cytomegalovirus is linked with the viral “footprint” in clinical samples

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-05-28 DOI:10.1016/j.cyto.2024.156654

Luna-faye Veld , Shelley Waters , Ashley Irish , Patricia Price , Silvia Lee

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Abstract

Persistent infections with human cytomegalovirus (HCMV) affect the hosts’ immune system and have been linked with chronic inflammation and cardiovascular disease. These effects may be influenced by a HCMV-encoded homologue of the anti-inflammatory cytokine, IL-10 (cmvIL-10). To assess this, we quantitated cmvIL-10 in plasma from renal transplant recipients (RTR) and healthy adults.

Detectable levels of cmvIL-10 associated with seropositivity in RTR, but were found in some seronegative healthy adults. RTR with detectable cmvIL-10 had elevated interferon-γ T-cell responses to HCMV antigens, whilst cmvIL-10 in healthy adults associated with reduced populations of terminally-differentiated T-cells – a known “footprint” of HCMV. Plasma cmvIL-10 associated with lower VCAM-1 levels in healthy adults.

The data suggest cmvIL-10 may suppress seroconversion and/or reduce the footprint of HCMV in healthy adults. This appears to be subverted in RTR by their high burden of HCMV and/or immune dysregulation associated with transplantation. A role for cmvIL-10 in protection of vascular health is discussed.

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人类巨细胞病毒编码的 IL-10 同源物与临床样本中的病毒 "足迹 "有关

人类巨细胞病毒（HCMV）的持续感染会影响宿主的免疫系统，并与慢性炎症和心血管疾病有关。这些影响可能受到 HCMV 编码的抗炎细胞因子 IL-10 的同源物（cmvIL-10）的影响。为了评估这一点，我们对肾移植受者（RTR）和健康成人血浆中的 cmvIL-10 进行了定量检测。可检测到 cmvIL-10 的 RTR 对 HCMV 抗原的干扰素-γ T 细胞反应升高，而健康成人的 cmvIL-10 与终末分化 T 细胞数量减少有关，终末分化 T 细胞是 HCMV 的已知 "足迹"。这些数据表明，cmvIL-10 可抑制血清转换和/或减少健康成人中 HCMV 的 "足迹"。这在 RTR 中似乎会被高 HCMV 负担和/或与移植相关的免疫失调所颠覆。本文讨论了 cmvIL-10 在保护血管健康方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.