{"title":"Mathematical models of the Arabidopsis circadian oscillator","authors":"Lucas Henao, Saúl Ares, Pablo Catalán","doi":"arxiv-2405.18006","DOIUrl":null,"url":null,"abstract":"We review the construction and evolution of mathematical models of the\nArabidopsis circadian clock, structuring the discussion into two distinct\nhistorical phases of modeling strategies: extension and reduction. The\nextension phase explores the bottom-up assembly of regulatory networks\nintroducing as many components and interactions as possible in order to capture\nthe oscillatory nature of the clock. The reduction phase deals with functional\ndecomposition, distilling complex models to their essential dynamical\nrepertoire. Current challenges in this field, including the integration of\nspatial considerations and environmental influences like light and temperature,\nare also discussed. The review emphasizes the ongoing need for models that\nbalance molecular detail with practical simplicity.","PeriodicalId":501325,"journal":{"name":"arXiv - QuanBio - Molecular Networks","volume":"18 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Molecular Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2405.18006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We review the construction and evolution of mathematical models of the
Arabidopsis circadian clock, structuring the discussion into two distinct
historical phases of modeling strategies: extension and reduction. The
extension phase explores the bottom-up assembly of regulatory networks
introducing as many components and interactions as possible in order to capture
the oscillatory nature of the clock. The reduction phase deals with functional
decomposition, distilling complex models to their essential dynamical
repertoire. Current challenges in this field, including the integration of
spatial considerations and environmental influences like light and temperature,
are also discussed. The review emphasizes the ongoing need for models that
balance molecular detail with practical simplicity.