{"title":"Elementary Flux Modes as CRN Gears for Free Energy Transduction","authors":"Massimo Bilancioni, Massimiliano Esposito","doi":"arxiv-2405.17960","DOIUrl":null,"url":null,"abstract":"We demonstrate that, for a chemical reaction network (CRN) engaged in energy\ntransduction, its optimal operation from a thermodynamic efficiency standpoint\nis contingent upon its working conditions. Analogously to the bicycle gear\nsystem, CRNs have at their disposal several transducing mechanisms\ncharacterized by different yields. We highlight the critical role of the CRN's\nelementary flux modes in determining this \"gearing\" and their impact on\nmaximizing energy transduction efficiency. Furthermore, we introduce an\nenzymatically regulated CRN, engineered to autonomously adjust its \"gear\",\nthereby optimizing its efficiency under different external conditions.","PeriodicalId":501325,"journal":{"name":"arXiv - QuanBio - Molecular Networks","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Molecular Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2405.17960","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We demonstrate that, for a chemical reaction network (CRN) engaged in energy
transduction, its optimal operation from a thermodynamic efficiency standpoint
is contingent upon its working conditions. Analogously to the bicycle gear
system, CRNs have at their disposal several transducing mechanisms
characterized by different yields. We highlight the critical role of the CRN's
elementary flux modes in determining this "gearing" and their impact on
maximizing energy transduction efficiency. Furthermore, we introduce an
enzymatically regulated CRN, engineered to autonomously adjust its "gear",
thereby optimizing its efficiency under different external conditions.
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