A Case of Squamous Cell Carcinoma Arising in Disseminated Superficial Porokeratosis

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-05-29 DOI:10.2147/ccid.s463569

Hui-E Zheng, Yun Wang, Shuhui Wu, Ming-Fang Zhu

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Abstract

Abstract: Porokeratosis (PK), characterized by keratotic lesions with an atrophic center and a prominent peripheral ridge, with a typical histological hallmark, namely, the cornoid lamella, has two forms: disseminated and localized. While PK often converts into squamous cell carcinoma (SCC), conversion from disseminated superficial porokeratosis (DSP) alone is rarely reported except for one case in which DSP and LP coexisted and converted to SCC. Here, we report the case of a patient with SCC converted from DSP alone, presenting with coin-sized macules on the bottom right of his waist that developed into an ulcer at the center. The patient underwent radiation therapy, which effectively treated the SCC but did not resolve the PK. This article highlights regular follow-up and undergo comprehensive diagnosis, both of which are beneficial to enable early detection and management of DSP that has converted to into SCC; in addition, standardized medical treatment may help improve the treatment therapeutic effect of in similar diseases.

Keywords: disseminated superficial porokeratosis, porokeratosis, squamous cell carcinoma

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播散性浅表角化病中的鳞状细胞癌病例

摘要：角化病（Porokeratosis，PK）的特征是具有萎缩中心和突出外周嵴的角化性病变，具有典型的组织学特征，即角质层，有两种形式：播散性和局部性。PK 常常转化为鳞状细胞癌（SCC），而由播散性浅表角化病（DSP）单独转化而来的病例却鲜有报道，只有一例 DSP 和 LP 同时存在并转化为 SCC。在此，我们报告了一例由单纯 DSP 转为 SCC 的患者，患者腰部右下方出现硬币大小的斑丘疹，斑丘疹中心发展为溃疡。患者接受了放射治疗，虽然有效治疗了 SCC，但并没有解决 PK 的问题。本文强调定期随访和全面诊断有利于早期发现和处理已转化为SCC的DSP；此外，规范化的医疗有助于提高同类疾病的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.