Clinical, Cosmetic and Investigational Dermatology最新文献

Atopic dermatitis (AD) affects 5-20% of the global population, with moderate-to-severe cases frequently requiring systemic therapy. The introduction of Janus kinase inhibitors (JAKi) has transformed therapeutic options, warranting a comprehensive analysis of the evolving research landscape. This bibliometric and visualized review aimed to identify global research hotspots, collaboration networks, and influential contributors in JAKi-related AD research. Publications were retrieved from the Web of Science Core Collection (2014-2024) using the terms "(Janus kinase inhibitors OR JAK) AND (atopic dermatitis)". Of 797 publications identified, 776 met inclusion criteria. Bibliometric mapping and visualization were conducted with VOSviewer, Excel, and Draw.io. The United States produced the most publications (34%), followed by Germany (12.62%), Japan (11.87%), and China (8.5%). The Icahn School of Medicine at Mount Sinai and Oregon Health & Science University led institutional output, while Kyoto University demonstrated the highest citation impact (82.57 citations per publication). Among authors, Emma Guttman-Yassky (25 publications) and Eric Simpson (22 publications) were the most prolific. Journal of Dermatological Treatment and Journal of the European Academy of Dermatology and Venereology were the leading publishing journals, while The Journal of Allergy and Clinical Immunology was the most co-cited. The most frequently cited reference was Oetjen (2017), with 674 citations. Keyword analysis highlighted "atopic dermatitis", "JAK inhibitors", "upadacitinib", and "baricitinib" as central themes, with abrocitinib and biologics emerging as newer hotspots. This study provides an updated overview of global research activity on JAK inhibitors in AD, addressing knowledge gaps, collaboration patterns, and future directions in targeted therapy.

Background: Granular parakeratosis (GP) is a rare keratinization disorder. Recent studies have suggested a possible association with exogenous irritants such as benzalkonium chloride (BAK); however, the clinical features of related cases have not yet been systematically characterized.

Aim: To analyze the clinical features, histopathological findings, and treatment outcomes of patients with GP induced by BAK exposure, with the aim of enhancing clinical recognition and management of this etiological subtype of GP.

Methods: A single-center retrospective study was conducted on eight patients diagnosed with BAK-associated GP confirmed both clinically and histopathologically, who presented between June 2024 and June 2025. Demographic data, clinical manifestations, histopathological changes, and treatment outcomes were collected and analyzed.

Results: Among the eight patients, six were male, with ages ranging from 4 to 43 years; four were children. Lesions were primarily distributed over the groin, trunk, neck, and upper chest, all presenting as erythematous-brown patches with characteristic parchment-like scaling. Histopathological examination in all cases revealed parakeratosis and retention of basophilic granules within the stratum corneum. Following definitive diagnosis and cessation of BAK exposure, combined with the use of emollients, complete resolution of lesions was achieved within 2 weeks to 1 month.

Conclusion: BAK can induce GP, which presents with certain characteristic features, notably the presence of parchment-like scaling that serves as a valuable clue for differential diagnosis. Early identification and elimination of the causative irritant are key to effective treatment. Pediatric patients may be more susceptible, and the development of GP may be related to individual predisposition and cumulative BAK exposure, warranting further investigation.

Purpose: Psoriasis is a chronic, immune-mediated skin disease that significantly affects patients' quality of life. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has emerged as a promising treatment for moderate to severe psoriasis, offering an alternative to biologics with a favorable safety profile. This study analyzes global research trends, key contributors, and emerging focus areas concerning apremilast in the treatment of psoriasis.

Patients and methods: Publications related to apremilast and psoriasis from 2008 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric and visual analyses were performed using tools such as VOSviewer, CiteSpace, and R 4.3.3.

Results: A total of 437 publications on apremilast and psoriasis were identified. The United States led with 158 publications, followed by Japan with 39 and Italy with 33. Celgene Corporation was the most productive institution, contributing 96 articles. The top journals include Journal of Dermatology, Journal of the European Academy of Dermatology and Venereology, and Journal of the American Academy of Dermatology. Key researchers, such as Shinichi Imafuku and Bruce Strober, were identified as leading contributors. Burst analysis revealed that since 2020, keywords like "monotherapy", "nail psoriasis", and "pathogenesis" have gained prominence, indicating emerging research areas.

Conclusion: This bibliometric analysis demonstrates that research on Apremilast for psoriasis has evolved from clinical trials focused on efficacy and safety to broader applications in real-world settings, including nail psoriasis and pathogenesis. Future research is likely to concentrate on long-term outcomes, optimizing treatment regimens, and addressing unmet needs in psoriasis management, particularly among specific patient subgroups.

Introduction and purpose: Marine collagens are environmentally friendly and biologically compatible collagens derived from aquatic organisms, including invertebrates like sponges and jellyfish. Starting from marine collagens as raw materials, sophisticated purification procedures lead to low-molecular-weight, bioactive fragments that are valuable functional ingredients for nutritional supplements, cosmeceuticals, and medical devices in regenerative medicine. From the mid-2010s to the late 2010s, several high-quality studies highlighted the skin bioregenerative properties of marine collagen-derived oligopeptides. The purpose of this review is to discuss these properties and their rationale.

Methods: This review only analyzes studies focused on skin regeneration published in indexed journals with significant impact factors (the rule was rigid for human studies), supplemented by a few contributions from Google Scholar for methodologically sound in vitro and animal studies.

Results: Activation of skin fibroblasts with high systemic bioavailability after oral intake supports the bioregenerative properties of hydrolyzed marine collagen. Marine collagen hydrolysates do not cause irritation or inflammation and have a negligible impact on pro-inflammatory mediators in animal studies. Preclinical research indicates that 50 µg/mL of hydrolyzed marine collagen peptides accelerates cell migration almost as effectively as 10 µg/mL of recombinant human epidermal growth factor, although the predictive value of in vitro studies for humans remains uncertain. Accelerated wound healing with collagen neosynthesis is associated with increased expression in immunohistochemistry of platelet-endothelial cell adhesion molecule-1, basic fibroblast growth factor, and transforming growth factor ß-1. Furthermore, enzyme-treated hydrolysates produced under acidic conditions exhibit antioxidant effects without affecting pro-inflammatory cytokines, while enzyme-treated hydrolysates under alkaline conditions have the opposite effect.

Conclusion: An increasing number of preclinical and human studies highlight the skin and overall bioregenerative properties of hydrolyzed marine collagens. Their high systemic intestinal absorption after oral intake distinguishes them from hydrolysates from other sources. Long-term safety should be a primary concern of future research.

Objective: Observational studies have consistently highlighted a robust clinical association between celiac disease (CD) and dermatitis herpetiformis (DH). Building on this foundation, the present study aims to investigate whether this observed relationship is underpinned by a causal genetic mechanism, providing insights into the potential hereditary basis of their connection.

Methods: This study employed bidirectional two-sample Mendelian randomization (MR) analysis to investigate the potential genetic causality between CD and DH, utilizing genome-wide association study (GWAS) summary data. To comprehensively examine the genetic relationship between CD and DH, we applied multiple MR methodologies. Furthermore, to enhance the robustness and credibility of our results, we conducted extensive sensitivity analyses.

Results: The fixed-effects inverse variance weighted (IVW) analysis revealed a significant positive genetic causal relationship between CD and DH (P = 0.001, odds ratio [OR] 95% confidence interval [CI]: 1.546 [1.195-1.999]). In contrast, no significant genetic causality was found in the reverse direction, from DH to CD (P = 0.113, OR 95% CI: 1.039 [0.991-1.090]). Notably, the MR analysis revealed no evidence of heterogeneity, further reinforcing the reliability of the fixed-effects IVW model. Additionally, sensitivity analyses confirmed the stability and robustness of the results, further validating the integrity of the conclusions drawn from the MR analysis.

Conclusion: The results of our study indicate that CD acts as a genetic susceptibility factor for the development of DH. Furthermore, the occurrence of DH in individuals with a history of CD appears to be attributed to a causal genetic relationship, suggesting that the genetic predisposition linked to CD may drive the manifestation of DH.

Background and objectives: Acne vulgaris is a common inflammatory skin disease with a strong hormonal component, especially in women. Hormonal therapies are increasingly used in moderate-to-severe or treatment-resistant cases. This review aims to summarize current evidence on the efficacy and safety of hormonal treatments for acne.

Materials and methods: A narrative review was conducted using PubMed, Scopus, and Web of Science, including studies published from 2010 to 2025. Eligible articles included randomized controlled trials, cohort studies, systematic reviews, and meta-analyses evaluating hormonal therapies such as combined oral contraceptives (COCs), spironolactone, cyproterone acetate, and topical antiandrogens (eg, clascoterone). Data were extracted on mechanisms of action, clinical efficacy, safety, and treatment indications to ensure consistent synthesis across therapies.

Results: Spironolactone consistently reduced lesion counts and improved quality of life in adult women, with good tolerability and a low risk of hyperkalemia. COCs effectively decreased both inflammatory and non-inflammatory lesions, with similar efficacy across different progestins. Clascoterone, a topical antiandrogen, showed significant improvement in lesion counts with minimal systemic absorption. Preliminary evidence also supports the use of topical spironolactone. Compared with antibiotics, hormonal therapies provide durable disease control and avoid antimicrobial resistance.

Conclusion: Hormonal therapies are effective and well-tolerated options for acne, particularly in women with hormonal patterns or refractory disease. By specifically targeting androgen-driven pathways, hormonal agents offer sustained improvement and should be incorporated into personalized acne management.

Perianal herpes simplex virus (HSV) infection represents a rarely reported clinical variant that is frequently misdiagnosed. We present a case of perianal HSV in a patient with a history of renal transplantation and type 2 diabetes mellitus. Following a previous diagnosis of perianal eczema, the patient's cutaneous lesions slowly worsened despite treatment with topical corticosteroids. Notably, the presence of well-demarcated superficial erosions, combined with immunosuppressive conditions including diabetes mellitus and renal transplantation, prompted targeted HSV screening which confirmed the diagnosis. This case underscores the importance of considering HSV testing in patients presenting with atypical perianal eruptions.

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, has a profound effect on skin health. This imbalance contributes to skin damage, premature aging, and the development of various dermatological conditions by modulating key signaling pathways with pro-inflammatory or antioxidant effects, such as NF-κB, JAK/STAT, Nrf2, MAPK/AP1, and SIRT1/FOXO. So, the application of antioxidant compounds, particularly those derived from natural sources, is essential for protecting the skin against ROS-induced damage. Sea cucumber, a marine invertebrate known for its remarkable regenerative capacity, contains bioactive compounds, including phenolics, proteins, and polysaccharides, which exhibit antioxidative and anti-inflammatory properties. These bioactive components may offer protective effects against oxidative stress within the skin. Therefore, this study will first evaluate the potential of sea cucumber-derived bioactive compounds in mitigating oxidative stress by examining their ability to counteract ROS-induced cellular damage caused by ROS and their potential role in promoting skin repair and regeneration. The review will also discuss the underlying mechanisms, including key signaling pathways, and explore the therapeutic potential of sea cucumber-derived exosomes as a novel strategy to treating oxidative stress-related skin disorders. Finally, a comparison is made between the efficacy of the sea cucumber crud extract with its derived exosome in treating oxidative stress-induced skin damage.

Purpose: Ferroptosis, a form of iron-dependent lipid peroxidation cell death. However, the mechanism of ferroptosis in psoriasis remains to be further investigated. Therefore, our research focuses on uncovering the role of ferroptosis in the pathogenesis of psoriasis and providing accurate biomarkers as therapeutic targets.

Patients and methods: We merged differentially expressed genes (DEGs) from the gene expression omnibus (GEO) with ferroptosis-related genes from FerrDb database. Key genes were further identified using weighted gene co-expression network analysis (WGCNA) and machine learning. Additionally, we used non-negative matrix factorization (NMF) clustering to identify two ferroptosis molecular subgroups.

Results: CHAC1, PARP9 and LCN2 are identified as key ferroptosis-related genes in psoriasis. The psoriatic skin samples were divided into cluster 1 and cluster 2, with cluster 1 being the more severe subtype of psoriatic lesions. The expression of CHAC1 had the highest correlation with activated CD4 T cells, neutrophil, regulatory T cell (Tregs) and type 2 T helper cell (Th2), which were significantly enriched in cluster1.

Conclusion: In conclusion, the ferroptosis associated diagnostic gene CHAC1 exacerbates psoriasis by regulating activated CD4 T cells, neutrophil, Tregs and Th2, serving as a reliable biomarker to predict patient survival.