DOCK–PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers

Abstract

Purpose

Information about developed positron emission tomography (PET) tracers and obtained clinical PET images is publicly available in a database. However, findings regarding the kinetic parameters of PET tracers are yet to be summarized. Therefore, in this study, we created an open-access database of central nervous system (CNS) kinetic parameters in the healthy human brain for existing PET tracers (DOCK–PET).

Methods

Our database includes information on the kinetic parameters and compounds of existing CNS–PET tracers. The kinetic parameter dataset comprises the analysis methods, V_T, BP_ND, K parameters, relevant literature, and study details. The list of PET tracers and kinetic parameter information was compiled through keyword-based searches of PubMed and the Molecular Imaging and Contrast Agent Database (MICAD). The kinetic parameters obtained, including V_T, BP_ND, and K parameters, were reorganized based on the defined brain anatomical regions. All data were rigorously double-checked before being summarized in Microsoft Excel and JavaScript Object Notation (JSON) formats.

Results

Of the 247 PET tracers identified through searches using the PubMed and MICAD websites, the kinetic parameters of 120 PET tracers were available. Among the 120 PET tracers, compound structures with chemical and physical properties were obtained from the PubChem website or the ChemDraw software. Furthermore, the affinity information of the 104 PET tracers was gathered from PubChem or extensive literature surveys of the 120 PET tracers.

Conclusions

We developed a comprehensive open-access database, DOCK–PET, that includes both kinetic parameters of healthy humans and compound information for existing CNS–PET tracers.