The association between ambient air pollution and colorectal cancer: a Mendelian randomization study.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2025-02-01 Epub Date: 2024-05-31 DOI:10.1080/09603123.2024.2361453

Xinshu Xu, Linhan Zhang, Yongkang An, Haitao Han, Ruobing Chen, Mengmeng Zhang, Yan Li, Shuangxi Zhang

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Abstract

Mounting epidemiology studies have reported the potential associations between ambient air pollution exposure and colorectal cancer (CRC). However, the genetic association between ambient air pollution and CRC remains unclear. Using the Genome-wide association study (GWAS) data from UK biobank, we explored the genetic association of CRC (5,657 cases and 372,016 controls) with four ambient air pollutants (PM_2.5, PM₁₀, NO₂, NO_x; n = 423,796 to 456,380) under the framework of Mendelian randomization (MR). Our results revealed a significant association between long-term NO₂ exposure (per 10 µg/m³) and increased CRC risk, with an odds ratio (OR) of 1.02 (95% confidence interval [CI]: 1.00-1.03), while no statistical association was found between CRC risk and the other air pollutants. Sensitivity analysis confirmed the robustness of the results. It is imperative to consider the impact of air pollution, particularly NO₂, in mitigating the risk of CRC.

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环境空气污染与结直肠癌之间的关系：孟德尔随机研究。

越来越多的流行病学研究报告了环境空气污染暴露与结直肠癌（CRC）之间的潜在联系。然而，环境空气污染与 CRC 之间的遗传关联仍不清楚。我们利用英国生物库的全基因组关联研究（GWAS）数据，在孟德尔随机化（MR）框架下探讨了 CRC（5657 例病例和 372 016 例对照）与四种环境空气污染物质（PM2.5、PM10、NO2、NOx；n = 423 796 至 456 380）的遗传关联。我们的研究结果表明，长期暴露于二氧化氮（每 10 微克/立方米）与 CRC 风险增加之间存在显着关联，几率比 (OR) 为 1.02（95% 置信区间 [CI]：1.00-1.03），而 CRC 风险与其他空气污染物之间没有统计学关联。敏感性分析证实了结果的稳健性。必须考虑空气污染（尤其是二氧化氮）对降低 CRC 风险的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.