Effects of composition and pH on the degradation of hyaluronate and carboxymethyl cellulose gels and release of nanocrystalline silver.

IF 3.1 4区 医学 Q2 BIOPHYSICS Journal of Applied Biomaterials & Functional Materials Pub Date : 2024-01-01 DOI:10.1177/22808000241257124
Colleen Nancy Ward, Payton E LeBlanc, Robert Edward Burrell
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Abstract

Adhesions are fibrous tissue connections which are a common complication of surgical procedures and may be prevented by protecting tissue surfaces and reducing inflammation. The combination of biodegradable polymers and nanocrystalline silver can be used to create an anti-inflammatory gel to be applied during surgery. In this study, sodium hyaluronate and sodium carboxymethyl cellulose were added in concentrations from 0.25% to 1% w/v to aqueous nanocrystalline silver solutions to create viscous gels. Gels were loaded into dialysis cassettes and placed in PBS for 3 days. pH was adjusted using potassium phosphate monobasic and sodium hydroxide. Release of silver into the PBS was measured at several time points. Polymer degradation was compared by measuring the viscosity of the gels before and after the experiment. Gels lost up to 84% of initial viscosity over 3 days and released between 24% and 41% of the added silver. Gels with higher initial viscosity did not have a greater degree of degradation, as measured by percent viscosity reduction, but still resulted in a higher final viscosity. Silver release was not significantly impacted by pH or composition, but still varied between experimental groups.

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成分和 pH 值对透明质酸和羧甲基纤维素凝胶降解及纳米银释放的影响
粘连是一种纤维组织连接,是外科手术的常见并发症,可通过保护组织表面和减少炎症来预防。可生物降解聚合物和纳米银的组合可用于制作消炎凝胶,在手术过程中使用。在这项研究中,透明质酸钠和羧甲基纤维素钠以 0.25% 至 1% w/v 的浓度添加到纳米银水溶液中,形成粘性凝胶。将凝胶装入透析盒,在 PBS 中放置 3 天,用磷酸二氢钾和氢氧化钠调节 pH 值。在几个时间点测量银在 PBS 中的释放量。通过测量实验前后凝胶的粘度来比较聚合物降解情况。凝胶在 3 天内降解了 84% 的初始粘度,并释放了 24% 至 41% 的添加银。初始粘度较高的凝胶降解程度并不高,以粘度降低的百分比来衡量,但最终粘度仍然较高。银的释放不受 pH 值或成分的明显影响,但各实验组之间仍有差异。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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