Antimicrobial therapeutic protein extraction from fruit waste and recent trends in their utilization against infections.

IF 3.5 3区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Bioprocess and Biosystems Engineering Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI:10.1007/s00449-024-03037-w
Aditya Upadhyay, Dharm Pal, Prashant Kumar Gupta, Awanish Kumar
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Abstract

Fruits are a very good source of various nutrients that can boost overall human health. In these days, the recovery of therapeutic compounds from different fruit wastes is trending in research, which might not only minimize the waste problem but also encounter a higher demand for various enzymes that could have antimicrobial properties against infectious diseases. The goal of this review is to focus on the recovery of therapeutic enzymes from fruit wastes and its present-day tendency for utilization. Here we discussed different parts of fruit waste, such as pulp, pomace, seed, kernel, peel, etc., that produce therapeutic enzymes like amylase, cellulose, lipase, laccase, pectinase, etc. These bioactive enzymes are present in different parts of fruit and could be used as therapeutics against various infectious diseases. This article provides a thorough knowledge compilation of therapeutic enzyme isolation from fruit waste on a single platform, distinctly informative, and significant review work on the topic that is envisioned to encourage further research ideas in these areas that are still under-explored. This paper explains the various aspects of enzyme isolation from fruit and vegetable waste and their biotherapeutic potential that could provide new insights into the development of biotherapeutics and attract the attention of researchers to enhance translational research magnitude further.

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从水果废料中提取抗菌治疗蛋白及其在抗感染方面的最新应用趋势。
水果是各种营养素的良好来源,可以促进人类的整体健康。如今,从不同的水果废料中回收治疗化合物已成为研究的趋势,这不仅可以最大限度地减少废物问题,还可以满足对各种酶的更高需求,这些酶具有抗菌特性,可预防传染性疾病。本综述的目的是关注从水果废料中回收治疗用酶及其当今的利用趋势。在这里,我们讨论了水果废料的不同部分,如果肉、果渣、种子、果核、果皮等,它们都能产生治疗酶,如淀粉酶、纤维素酶、脂肪酶、漆酶、果胶酶等。这些生物活性酶存在于水果的不同部位,可用作治疗各种传染性疾病的药物。本文对在单一平台上从水果废弃物中分离治疗性酶进行了全面的知识梳理,内容丰富,是对这一主题的重要综述,旨在鼓励在这些仍未得到充分开发的领域开展进一步的研究。本文阐述了从水果和蔬菜废弃物中分离酶的各个方面及其生物治疗潜力,可为生物治疗药物的开发提供新的见解,并吸引研究人员的注意力,进一步提升转化研究的规模。
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来源期刊
Bioprocess and Biosystems Engineering
Bioprocess and Biosystems Engineering 工程技术-工程:化工
CiteScore
7.90
自引率
2.60%
发文量
147
审稿时长
2.6 months
期刊介绍: Bioprocess and Biosystems Engineering provides an international peer-reviewed forum to facilitate the discussion between engineering and biological science to find efficient solutions in the development and improvement of bioprocesses. The aim of the journal is to focus more attention on the multidisciplinary approaches for integrative bioprocess design. Of special interest are the rational manipulation of biosystems through metabolic engineering techniques to provide new biocatalysts as well as the model based design of bioprocesses (up-stream processing, bioreactor operation and downstream processing) that will lead to new and sustainable production processes. Contributions are targeted at new approaches for rational and evolutive design of cellular systems by taking into account the environment and constraints of technical production processes, integration of recombinant technology and process design, as well as new hybrid intersections such as bioinformatics and process systems engineering. Manuscripts concerning the design, simulation, experimental validation, control, and economic as well as ecological evaluation of novel processes using biosystems or parts thereof (e.g., enzymes, microorganisms, mammalian cells, plant cells, or tissue), their related products, or technical devices are also encouraged. The Editors will consider papers for publication based on novelty, their impact on biotechnological production and their contribution to the advancement of bioprocess and biosystems engineering science. Submission of papers dealing with routine aspects of bioprocess engineering (e.g., routine application of established methodologies, and description of established equipment) are discouraged.
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