The effect of methylphenidate on the dopamine and growth hormone response to exercise in children with attention-deficit hyperactivity disorder

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2024-06-01 DOI:10.1016/j.ghir.2024.101596
Dan Nemet , Sigal Ben-Zaken , Alon Eliakim
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Abstract

Purpose

To assess the growth hormone (GH) and Dopamine (DA) response to exercise in children with attention-deficit hyperactivity disorder (ADHD) with and without methylphenidate (MP). We hypothesized that the GH and DA response to the exercise with MP would be siginicantly lower.

Methods

Twenty children participated in the study (12 males and 8 females, age range 9–13 years). Ten with ADHD and 10 controls. Participants with ADHD performed an exercise test twice, with and without MP while controls performed one exercise test. Blood samples for GH and DA were collected before, at peak, 30 and 60 min after the end of exercise.

Results

Compared to controls, children with ADHD with and without MP, had a significantly lower GH (P < .002) and DA (P < .01) responses to exercise. In participants with ADHD, a significantly greater GH response (p < .04) to exercise was found when MP administered to the children before exercise, yet this response was still significantly lower than controls.

Conclusions

GH and DA excretion after an exercise challenge in children with ADHD is impaired. MP slightly attenuates the GH blunted response. This may link ADHD with growth impairment in some children and explain previous findings indicating that the final adult height is usually not compromised in children with ADHD treated with MP. The combined exercise and stimulant treatment therapeutic effects needs to be further explored.

Trial registration number: NCT00945971

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哌醋甲酯对注意力缺陷多动障碍儿童运动时多巴胺和生长激素反应的影响。
目的:评估服用和未服用哌醋甲酯(MP)的注意力缺陷多动障碍(ADHD)儿童对运动的生长激素(GH)和多巴胺(DA)反应。我们假设,服用哌醋甲酯(MP)的儿童对运动的促生长激素(GH)和多巴胺(DA)反应会明显降低:20名儿童(12男8女,年龄在9-13岁之间)参加了研究。其中 10 名患有多动症,10 名为对照组。患有多动症的儿童进行了两次运动测试,分别测试了有无多巴胺,而对照组儿童只进行了一次运动测试。在运动前、运动高峰期、运动结束后 30 分钟和 60 分钟采集血液样本,检测 GH 和 DA:结果:与对照组相比,患有多动症的儿童无论有无运动神经元异常,其 GH 都明显较低(P 结论:运动神经元异常儿童的 GH 和 DA 排泄量明显低于对照组):多动症儿童在运动挑战后的促生长激素和去甲肾上腺素排泄受到影响。多巴胺可轻微减轻 GH 反应的减弱。这可能会将多动症与某些儿童的生长障碍联系起来,并解释了为什么之前的研究结果表明,接受 MP 治疗的多动症儿童最终的成年身高通常不会受到影响。运动与兴奋剂联合治疗的疗效有待进一步探讨:NCT00945971.
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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