Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-31 DOI:10.1016/j.taap.2024.116980

Fang Zhou , Yu-Xin Guo , Rui Gao , Xiao-Yu Ji , Yu-Xuan Tang , Li-Bin Wang , Yuan Zhang , Xing Li

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Abstract

Multiple sclerosis (MS) is a class of autoimmune diseases mainly caused by the immune system attacking the myelin sheath of the axons in the nervous system. Although the pathogenesis of MS is complex, studies have shown that dendritic cells (DCs) play a vital role in the pathogenesis of MS. Quercetin (QU) has a unique advantage in clinical application, especially for treating autoimmune diseases. However, the mechanism of QU in the treatment of experimental autoimmune encephalomyelitis (EAE) remains unclear. In this study, we explore the potential role of QU in EAE. Finally, we find that QU has anti-inflammatory activities and neural protective effects in EAE. The experimental results suggest that the cellular basis for QU's function is to inhibit the activation of DCs while modulating the Th17 cell differentiation in the co-culture system. Further, QU may target STAT4 to inhibit its activation in DCs. This work will be of great significance for the future development and utilization of QU.

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槲皮素在治疗实验性自身免疫性脑脊髓炎中通过靶向 STAT4 调节树突状细胞活化

多发性硬化症（MS）是一类自身免疫性疾病，主要由免疫系统攻击神经系统轴突的髓鞘引起。虽然多发性硬化症的发病机制十分复杂，但研究表明，树突状细胞（DCs）在多发性硬化症的发病机制中起着至关重要的作用。槲皮素（QU）在临床应用中具有独特的优势，尤其是在治疗自身免疫性疾病方面。然而，槲皮素治疗实验性自身免疫性脑脊髓炎（EAE）的机制仍不清楚。在本研究中，我们探讨了 QU 在 EAE 中的潜在作用。最后，我们发现 QU 在 EAE 中具有抗炎活性和神经保护作用。实验结果表明，QU 发挥作用的细胞基础是抑制 DCs 的活化，同时调节共培养系统中 Th17 细胞的分化。此外，QU可能以STAT4为靶点，抑制其在DCs中的激活。这项工作对 QU 未来的开发和利用具有重要意义。

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