Shahrokh Mojarradgandoukmolla, Hasan Akan, Takım Kasım, Sevgi Durna Dastan, Hatice Gumushan Aktas
{"title":"Anticancer and Cytotoxic Activities of Some Trigonella Species on MCF-7, L929 and HeLa Cell Lines","authors":"Shahrokh Mojarradgandoukmolla, Hasan Akan, Takım Kasım, Sevgi Durna Dastan, Hatice Gumushan Aktas","doi":"10.1134/s1062359023603567","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p><i>Trigonella filipes</i> Boiss, <i>Trigonella strangulata</i> Boiss., and <i>Trigonella uninata</i> Banks and Sol., are three commonly used species that grow well in Iraq’s northern suburbs and are frequently consumed and used in traditional medicine. The current study was planned to assess and identify the active chemicals in these plant species, as well as to analyze their anticancer and antiprofeliration effects in rats treated with alcohol and cholesterol. Plant extracts were tested for oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS). Administration of <i>Trigonella foenum-graecum</i> and <i>Trigonella monantha</i> significantly improved these changes in diseased rats. MTT cytotoxicity test was used to investigate the cytotoxic properties of <i>Trigonella filipes</i>, <i>Trigonella strangulata,</i> and <i>Trigonella uncinata</i> plant extracts on three distinct cell lines in varied concentrations (1–10–100–1000 g/mL) after 24 h of incubation. The results were supported that these three plant taxa have high phytochemical compounds that have physiological effects such as inhibit cell proliferation, improving the function of liver and kidney function, and antioxidants effect.</p>","PeriodicalId":55366,"journal":{"name":"Biology Bulletin","volume":"55 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology Bulletin","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s1062359023603567","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Trigonella filipes Boiss, Trigonella strangulata Boiss., and Trigonella uninata Banks and Sol., are three commonly used species that grow well in Iraq’s northern suburbs and are frequently consumed and used in traditional medicine. The current study was planned to assess and identify the active chemicals in these plant species, as well as to analyze their anticancer and antiprofeliration effects in rats treated with alcohol and cholesterol. Plant extracts were tested for oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS). Administration of Trigonella foenum-graecum and Trigonella monantha significantly improved these changes in diseased rats. MTT cytotoxicity test was used to investigate the cytotoxic properties of Trigonella filipes, Trigonella strangulata, and Trigonella uncinata plant extracts on three distinct cell lines in varied concentrations (1–10–100–1000 g/mL) after 24 h of incubation. The results were supported that these three plant taxa have high phytochemical compounds that have physiological effects such as inhibit cell proliferation, improving the function of liver and kidney function, and antioxidants effect.
期刊介绍：
Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
