{"title":"Advantageous properties of a new fungicide, isofetamid","authors":"Shuko Nishimi, Yuzuka Abe, Nanami Kuwahara, Akihiro Nishimura, Shintaro Tsukuda, Satoshi Araki, Kosuke Tsunematsu, Yohei Fukumori, Munekazu Ogawa, Kazumi Suzuki, Shigeru Mitani","doi":"10.1584/jpestics.d23-067","DOIUrl":null,"url":null,"abstract":"</p><p>The fungicidal properties of a new fungicide, isofetamid, were examined to assess its antifungal spectrum, mode of action, and effects on the infection process of <i>Botrytis cinerea</i>. Additionally, we investigated its fungicidal activity against isolates of <i>B. cinerea</i> resistant to existing fungicides. In mycelial growth inhibition tests, isofetamid exhibited excellent fungicidal activity against ascomycetes but showed no activity against basidiomycetes and oomycetes. Respiratory enzyme assay using mitochondria revealed that isofetamid inhibited succinate dehydrogenase activity prepared from <i>B. cinerea</i> and other ascomycetes fungi used in the study. On the other hand, the activity of mitochondria prepared from <i>Pythium</i>, potato and rat were not inhibited. Isofetamid inhibited also many stages of the infection processes in <i>B. cinerea</i>. Furthermore, it exhibited high fungicidal activity against <i>B. cinerea</i> isolates that were resistant to existing fungicides.</p>\n<p></p>\n<img alt=\"\" src=\"https://www.jstage.jst.go.jp/pub/jpestics/advpub/0/advpub_D23-067/figure/advpub_D23-067.png\"/>\n<span style=\"padding-left:5px;\">Fullsize Image</span>","PeriodicalId":16712,"journal":{"name":"Journal of Pesticide Science","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pesticide Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1584/jpestics.d23-067","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENTOMOLOGY","Score":null,"Total":0}
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Abstract
The fungicidal properties of a new fungicide, isofetamid, were examined to assess its antifungal spectrum, mode of action, and effects on the infection process of Botrytis cinerea. Additionally, we investigated its fungicidal activity against isolates of B. cinerea resistant to existing fungicides. In mycelial growth inhibition tests, isofetamid exhibited excellent fungicidal activity against ascomycetes but showed no activity against basidiomycetes and oomycetes. Respiratory enzyme assay using mitochondria revealed that isofetamid inhibited succinate dehydrogenase activity prepared from B. cinerea and other ascomycetes fungi used in the study. On the other hand, the activity of mitochondria prepared from Pythium, potato and rat were not inhibited. Isofetamid inhibited also many stages of the infection processes in B. cinerea. Furthermore, it exhibited high fungicidal activity against B. cinerea isolates that were resistant to existing fungicides.
我们研究了一种新型杀真菌剂异菲他胺的杀真菌特性，以评估其抗真菌谱、作用模式以及对灰霉病菌感染过程的影响。此外，我们还研究了它对对现有杀真菌剂有抗药性的灰霉病菌分离株的杀真菌活性。在菌丝生长抑制试验中，异菲他米德对子囊菌表现出极佳的杀菌活性，但对基枝菌和卵菌没有活性。利用线粒体进行的呼吸酶测定显示，异菲他胺抑制了从 B. cinerea 和研究中使用的其他子囊菌中制备的琥珀酸脱氢酶的活性。另一方面，从 Pythium、马铃薯和大鼠中制备的线粒体的活性没有受到抑制。Isofetamid 还能抑制 B. cinerea 感染过程的许多阶段。此外，它还对对现有杀真菌剂具有抗药性的棉铃虫分离物具有很高的杀真菌活性。
期刊介绍：
The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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