The bioproduction of astaxanthin: A comprehensive review on the microbial synthesis and downstream extraction

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-05-31 DOI:10.1016/j.biotechadv.2024.108392

Dawei Zhou , Zhengyue Fei , Guannan Liu , Yujia Jiang , Wankui Jiang , Carol Sze Ki Lin , Wenming Zhang , Fengxue Xin , Min Jiang

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Abstract

Astaxanthin is a valuable orange-red carotenoid with wide applications in agriculture, food, cosmetics, pharmaceuticals and nutraceuticals areas. At present, the biological synthesis of astaxanthin mainly relies on Haematococcus pluvialis and Xanthophyllomyces dendrorhous. With the rapid development of synthetic biology, more recombinant microbial hosts have been genetically constructed for astaxanthin production including Escherichia coli, Saccharomyces cerevisiae and Yarrowia lipolytica. As multiple genes (15) were involved in the astaxanthin synthesis, it is particularly important to adopt different strategies to balance the metabolic flow towards the astaxanthin synthesis. Furthermore, astaxanthin is a fat-soluble compound stored intracellularly, hence efficient extraction methods are also essential for the economical production of astaxanthin. Several efficient and green extraction methods of astaxanthin have been reported in recent years, including the superfluid extraction, ionic liquid extraction and microwave-assisted extraction. Accordingly, this review will comprehensively introduce the advances on the astaxanthin production and extraction by using different microbial hosts and strategies to improve the astaxanthin synthesis and extraction efficiency.

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虾青素的生物生产：关于微生物合成和下游提取的全面综述。

虾青素是一种珍贵的橙红色类胡萝卜素，在农业、食品、化妆品、医药和营养保健品等领域有着广泛的应用。目前，虾青素的生物合成主要依靠血球菌和黄ophyllomyces dendrorhous。随着合成生物学的快速发展，更多用于生产虾青素的基因重组微生物宿主被构建出来，包括大肠杆菌、酿酒酵母和脂溶性亚罗酵母。由于多个基因（15 个）参与了虾青素的合成，因此采用不同的策略来平衡虾青素合成的新陈代谢流尤为重要。此外，虾青素是一种储存在细胞内的脂溶性化合物，因此高效的提取方法对于虾青素的经济生产也至关重要。近年来已报道了几种高效、绿色的虾青素提取方法，包括超流体提取、离子液体提取和微波辅助提取。因此，本综述将全面介绍利用不同微生物宿主生产和提取虾青素的进展，以及提高虾青素合成和提取效率的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.