Association between loneliness and mild cognitive impairment in older adults: a meta-analysis of longitudinal studies.

IF 2.8 3区 医学 Q3 GERIATRICS & GERONTOLOGY Aging & Mental Health Pub Date : 2024-12-01 Epub Date: 2024-06-02 DOI:10.1080/13607863.2024.2358079
Kexin Fan, Betsy Seah, Zhiyuan Lu, Tao Wang, Yunping Zhou
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Abstract

Objectives: Prior studies reporting the effects of loneliness on mild impairment cognitive (MCI) have generated inconsistent results. This meta-analysis aimed to investigate the longitudinal association between loneliness and risk of MCI among community-dwelling middle-aged and older adults.

Method: Five electronic databases were searched from inception to 9 May 2023. Eligible studies examined the longitudinal association between loneliness and cognitive outcomes, including incident MCI, cognitive impairment, and cognitive decline. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects meta-analysis. Sensitivity analysis and subgroup analysis were conducted. Publication bias was examined using Egger's and Begg tests.

Results: Eight studies were included. Among the 45,032 participants, 10,570 were diagnosed with MCI/cognitive decline. Loneliness was positively associated with an increased risk of MCI (overall OR = 1.14; 95% CI = 1.05, 1.23), with moderate heterogeneity (I2 = 44.2%). Sensitivity analysis have minimal influence on the aforementioned pooled effect. Subgroup analyses indicated stronger associations in studies which employed incident MCI as cognitive outcome (OR = 2.55, 95%CI = 1.31, 1.83), were conducted in non-Asia countries (OR = 1.52, 95%CI = 0.95, 1.20), and reported no depression adjustment (OR = 1.51, 95%CI = 1.04, 1.25). The association between loneliness and MCI was stronger among males compare to females. The Egger test and Begg test showed no evidence of significant publication bias (p = .493; p = .474).

Conclusion: The findings indicated that loneliness was associated with an increased risk of MCI. Future longitudinal studies should evaluate potential cases of MCI through comprehensive clinical assessments by practitioners to draw robust findings on the association of loneliness with MCI.

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老年人孤独感与轻度认知障碍之间的关系:纵向研究荟萃分析。
研究目的之前有关孤独对轻度认知障碍(MCI)影响的研究结果并不一致。本荟萃分析旨在研究居住在社区的中老年人孤独感与 MCI 风险之间的纵向联系:方法:检索了从开始到 2023 年 5 月 9 日的五个电子数据库。符合条件的研究考察了孤独感与认知结果(包括MCI事件、认知障碍和认知能力下降)之间的纵向联系。采用随机效应或固定效应荟萃分析法计算了比率(OR)和95%置信区间(CI)。进行了敏感性分析和亚组分析。使用 Egger 检验和 Begg 检验检查了发表偏倚:结果:共纳入八项研究。在 45,032 名参与者中,有 10,570 人被诊断为 MCI/认知能力下降。孤独与 MCI 风险的增加呈正相关(总体 OR = 1.14;95% CI = 1.05,1.23),异质性适中(I2 = 44.2%)。敏感性分析对上述汇总效应的影响微乎其微。亚组分析表明,将MCI事件作为认知结果的研究(OR = 2.55,95%CI = 1.31,1.83)、在非亚洲国家进行的研究(OR = 1.52,95%CI = 0.95,1.20)和未报告抑郁调整的研究(OR = 1.51,95%CI = 1.04,1.25)之间的关联性更强。与女性相比,男性的孤独感与 MCI 之间的关系更为密切。Egger检验和Begg检验均未显示明显的发表偏倚(P = .493;P = .474):结论:研究结果表明,孤独与 MCI 风险的增加有关。未来的纵向研究应通过从业人员的全面临床评估来评估潜在的MCI病例,从而得出孤独与MCI相关性的可靠结论。
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来源期刊
Aging & Mental Health
Aging & Mental Health 医学-精神病学
CiteScore
7.00
自引率
2.90%
发文量
176
审稿时长
4-8 weeks
期刊介绍: Aging & Mental Health provides a leading international forum for the rapidly expanding field which investigates the relationship between the aging process and mental health. The journal addresses the mental changes associated with normal and abnormal or pathological aging, as well as the psychological and psychiatric problems of the aging population. The journal also has a strong commitment to interdisciplinary and innovative approaches that explore new topics and methods. Aging & Mental Health covers the biological, psychological and social aspects of aging as they relate to mental health. In particular it encourages an integrated approach for examining various biopsychosocial processes and etiological factors associated with psychological changes in the elderly. It also emphasizes the various strategies, therapies and services which may be directed at improving the mental health of the elderly and their families. In this way the journal promotes a strong alliance among the theoretical, experimental and applied sciences across a range of issues affecting mental health and aging. The emphasis of the journal is on rigorous quantitative, and qualitative, research and, high quality innovative studies on emerging topics.
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