Autism spectrum disorder identification with multi-site functional magnetic resonance imaging

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by enduring difficulties in social interaction and communication. People analyzed with ASD may display repetitive behaviors and limited interests. Autism is classified as a spectrum disorder, implying that the symptom intensity might range from mild to severe depending on the individual. To detect ASD in this paper an attribute feature graph approach is designed by using the stastical dependencies features that necessarily accomplish the diagnosis of ASD. In the first phase the features extracted are designed based on the functional magnetic resonance imaging (fMRI) data, in the next-step the attribute feature graph layer learns the features of the node information of various nodes by ASD classification. Further, in the third step, it is employed to independently extract distinguishing features from the functional connectivity matrices of the brain that are derived from fMRI. The custom convolutional neural network (CNN) used in this study is trained on a comprehensive dataset comprising individuals diagnosed with ASD and typically developing individuals. In the fourth stage, a prototype learning is developed to augment the classification performance of the custom-CNN. The experimental analysis further carried out states that the proposed model works efficiently in comparison with the existing system.