Simulation of Non-Newtonian Blood Flow in Diverging Bifurcated Vessels

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.47176/jafm.17.6.2329
J. Chu, L. L. Xiao, C. S. Lin, S. Liu, K. X. Zhang, P. Wei
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Abstract

Bifurcated vessels represent a typical vascular unit of the cardiovascular system. In this study, the blood flow in symmetric and asymmetric bifurcated vessels are simulated based on computational fluid dynamics method. The blood is modeled as non-Newtonian fluid, and the pulsatile flow velocity is applied on the inlet. The effects of the fluid model, bifurcation angle and symmetry of the geometry of the vessel are investigated. The results show that the wall shear stress (WSS) on the outer wall of daughter branches for the non-Newtonian fluid flow is greater than that for Newtonian fluid flow, and the discrepancy between the flow of two fluid models is obvious at relatively low flow rates. With the bifurcation angle increases, the peak axial velocity of the cross-section of daughter branch decreases, so the WSS increases. For the non-Newtonian fluid flow in the asymmetric bifurcated vessels, more flow passes through the daughter vessel with a lower angle, and the WSS along the outer wall of which is lower. Furthermore, the region with a low time-averaged wall stress (TAWSS) and high oscillating shear index(OSI) distributed on the outer wall of bifurcation vessels are larger for the flow in the vessel with smaller bifurcation angle
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发散分叉血管中的非牛顿血流模拟
分叉血管是心血管系统中典型的血管单元。本研究基于计算流体动力学方法模拟了对称和非对称分叉血管中的血流。血液被模拟为非牛顿流体,入口处采用脉动流速。研究了流体模型、分叉角度和血管几何对称性的影响。结果表明,非牛顿流体流动时子分支外壁的壁面剪应力(WSS)大于牛顿流体流动时的壁面剪应力(WSS),而且在流速相对较低时,两种流体模型的流动差异明显。随着分叉角的增大,子分支横截面的峰值轴向速度减小,因此 WSS 增大。对于非牛顿流体在非对称分叉容器中的流动,更多的流体通过角度较小的子容器,沿其外壁的 WSS 值较低。此外,在分叉角度较小的容器中,分叉容器外壁分布的低时间平均壁面应力(TAWSS)和高振荡剪切指数(OSI)区域更大。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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