Targeting anoikis resistance as a strategy for cancer therapy

IF 15.8 1区 医学 Q1 PHARMACOLOGY & PHARMACY Drug Resistance Updates Pub Date : 2024-06-01 DOI:10.1016/j.drup.2024.101099
Yumin Wang , Sihang Cheng , Joshua S. Fleishman , Jichao Chen , Hailin Tang , Zhe-Sheng Chen , Wenkuan Chen , Mingchao Ding
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Abstract

Anoikis, known as matrix detachment-induced apoptosis or detachment-induced cell death, is crucial for tissue development and homeostasis. Cancer cells develop means to evade anoikis, e.g. anoikis resistance, thereby allowing for cells to survive under anchorage-independent conditions. Uncovering the mechanisms of anoikis resistance will provide details about cancer metastasis, and potential strategies against cancer cell dissemination and metastasis. Here, we summarize the principal elements and core molecular mechanisms of anoikis and anoikis resistance. We discuss the latest progress of how anoikis and anoikis resistance are regulated in cancers. Furthermore, we summarize emerging data on selective compounds and nanomedicines, explaining how inhibiting anoikis resistance can serve as a meaningful treatment modality against cancers. Finally, we discuss the key limitations of this therapeutic paradigm and possible strategies to overcome them. In this review, we suggest that pharmacological modulation of anoikis and anoikis resistance by bioactive compounds could surmount anoikis resistance, highlighting a promising therapeutic regimen that could be used to overcome anoikis resistance in cancers.

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以抗药性为靶点的癌症治疗策略
Anoikis被称为基质脱落诱导的细胞凋亡或脱落诱导的细胞死亡,对于组织的发育和平衡至关重要。癌细胞发展出逃避anoikis的方法,如anoikis抗性,从而使细胞在不依赖锚的条件下存活。揭示anoikis抗性的机制将提供有关癌症转移的详细信息,以及应对癌细胞扩散和转移的潜在策略。在此,我们总结了anoikis和anoikis抗性的主要因素和核心分子机制。我们还将讨论癌症中嗜酸酶和嗜酸酶抗性调控的最新进展。此外,我们还总结了有关选择性化合物和纳米药物的新兴数据,解释了抑制 anoikis 抗性如何成为一种有意义的癌症治疗方式。最后,我们讨论了这种治疗模式的主要局限性以及克服这些局限性的可能策略。在这篇综述中,我们认为通过生物活性化合物对anoikis和anoikis抗性进行药理调节可以克服anoikis抗性,并强调了一种可用于克服癌症中anoikis抗性的有前途的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug Resistance Updates
Drug Resistance Updates 医学-药学
CiteScore
26.20
自引率
11.90%
发文量
32
审稿时长
29 days
期刊介绍: Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research
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