Microcephaly type 22 and autism spectrum disorder: A case report and review of literature.

IF 8.3 2区医学 Q1 Medicine Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-06-03 DOI:10.1080/19585969.2024.2359918

Jiqiang Ma, Yu'e Liu, Kaijun Zhao

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Abstract

Introduction: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a multifaceted etiology. This case report explores the ischemic cryptogenic vascular dissection as a potential underlying cause of ASD.

Methods: A 9-year-old child presented with symptoms of ASD, including social interaction difficulties, repetitive behaviors, and cognitive challenges. Despite conventional ASD treatments, significant improvement was only observed after addressing an underlying ischemic cryptogenic vascular dissection identified through DCE-CT.

Results: Following a reconstructive treatment approach to the vascular dissection, the patient showed marked improvement in cognitive functions, social abilities, and a reduction in ASD-related symptoms whether during the perioperative period or during approximately 5-month follow-up.

Conclusion: This case suggests that ischemic cryptogenic vascular dissection may contribute to the symptoms of ASD. Identifying and treating underlying vascular anomalies may offer a new avenue for mitigating ASD symptoms, emphasizing the need for comprehensive diagnostic estimations in ASD management.

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小头畸形 22 型和自闭症谱系障碍：病例报告和文献综述。

简介自闭症谱系障碍（ASD）是一种复杂的神经发育障碍，具有多方面的病因。本病例报告探讨了缺血性隐源性血管夹层作为 ASD 潜在病因的可能性：一名 9 岁儿童出现 ASD 症状，包括社交互动困难、重复行为和认知挑战。尽管采用了传统的 ASD 治疗方法，但只有在通过 DCE-CT 确定潜在的缺血性隐源性血管夹层后，才能观察到明显的改善：结果：在对血管夹层进行重建治疗后，患者的认知功能和社交能力明显改善，无论是在围手术期还是在约 5 个月的随访期间，ASD 相关症状均有所减轻：本病例表明，缺血性隐源性血管夹层可能是导致 ASD 症状的原因之一。鉴别和治疗潜在的血管异常可能为减轻 ASD 症状提供了一条新途径，强调了在 ASD 治疗中进行全面诊断评估的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health

CiteScore

19.30

自引率

1.20%

发文量

期刊介绍： Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.