Ascorbic acid and thiamine as adjunctive therapy for ovine pneumonia

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Small Ruminant Research Pub Date : 2024-05-29 DOI:10.1016/j.smallrumres.2024.107293
Amir Massoudi, Ghader Jalilzadeh-Amin , Bahram Dalir- Naghadeh, Siamak Asri-Rezaei
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Abstract

The purpose of this study was to investigate the effectiveness of ascorbic acid and thiamine as an adjunctive therapy with antibiotics in treatment of sheep affected with pneumonia. Twenty male lambs (8–12 months old) with clinical signs of pneumonia were randomly allocated into 1 of 4 treatment groups: A (antibiotics alone), B (antibiotics + thiamine), C (antibiotics + ascorbic acid), and D (antibiotics + thiamine + ascorbic acid). A separate group of five male healthy lambs, matching for weight and age served as the control group, received only distilled water. The primary outcomes were the rate of change in the severity of clinical signs of pneumonia and acute phase protein concentrations, assessed at days 1, 3, 6, and 14 after administration. All groups displayed clinical improvement, with groups C and D exhibiting faster resolution of dyspnea and nasal discharge. Serum total protein, ceruloplasmin, and haptoglobin decreased in all groups, with group D showing the fastest decline. Albumin levels increased significantly in all groups, especially in group D. Fibrinogen levels decreased most notably in D. WBC counts in group D converged with the control group on day 14. In conclusion, this study indicates that co-administration of thiamine and ascorbic acid alongside antibiotics may be more effective in treating pneumonia compared to antibiotics alone. Pneumonic animals receiving both thiamine and ascorbic acid displayed faster resolution of clinical signs and a more pronounced improvement in markers of inflammation compared to other treatment groups.

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抗坏血酸和硫胺素作为绵羊肺炎的辅助疗法
本研究旨在探讨抗坏血酸和硫胺素作为抗生素的辅助疗法对治疗绵羊肺炎的效果。20 只临床症状为肺炎的雄性羔羊(8-12 个月大)被随机分配到 4 个治疗组中的 1 个:A组(单独使用抗生素)、B组(抗生素+硫胺素)、C组(抗生素+抗坏血酸)和D组(抗生素+硫胺素+抗坏血酸)。另一组为对照组,由五只体重和年龄相匹配的雄性健康羔羊组成,只饮用蒸馏水。主要结果是在用药后第 1、3、6 和 14 天评估肺炎临床症状严重程度的变化率和急性期蛋白浓度。所有组的临床症状都有所改善,C 组和 D 组的呼吸困难和流鼻涕症状缓解得更快。所有组的血清总蛋白、脑磷脂和血红蛋白都有所下降,其中 D 组下降最快。白蛋白水平在所有组别中都有明显上升,尤其是 D 组。D 组的白细胞计数在第 14 天与对照组趋同。总之,本研究表明,与单独使用抗生素相比,同时服用硫胺素和抗坏血酸治疗肺炎可能更有效。与其他治疗组相比,同时接受硫胺素和抗坏血酸治疗的肺炎动物临床症状缓解更快,炎症指标改善更明显。
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来源期刊
Small Ruminant Research
Small Ruminant Research 农林科学-奶制品与动物科学
CiteScore
3.10
自引率
11.10%
发文量
210
审稿时长
12.5 weeks
期刊介绍: Small Ruminant Research publishes original, basic and applied research articles, technical notes, and review articles on research relating to goats, sheep, deer, the New World camelids llama, alpaca, vicuna and guanaco, and the Old World camels. Topics covered include nutrition, physiology, anatomy, genetics, microbiology, ethology, product technology, socio-economics, management, sustainability and environment, veterinary medicine and husbandry engineering.
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