Samantha M. McCabe, Hannah Gardiner, Calum Mullen, Gregory Q. Wallace, Neil C. Shand, Alexander B. Mullen, Linda Horan, Duncan Graham, Karen Faulds and Marie Boyd
{"title":"Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy†","authors":"Samantha M. McCabe, Hannah Gardiner, Calum Mullen, Gregory Q. Wallace, Neil C. Shand, Alexander B. Mullen, Linda Horan, Duncan Graham, Karen Faulds and Marie Boyd","doi":"10.1039/D4AN00617H","DOIUrl":null,"url":null,"abstract":"<p >Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for <em>in vivo</em> studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/an/d4an00617h?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analyst","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/an/d4an00617h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.
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