Alaa Alqudah, Alaa A. Aljabali, Omar Gammoh, Murtaza M. Tambuwala
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引用次数: 0
Abstract
Overcoming the blood–brain barrier (BBB) remains a substantial challenge in CNS drug delivery. This review explores the potential of lipid-based nanoparticles (NPs) such as liposomes and solid lipid NPs to overcome this obstacle. As demonstrated in preclinical studies, these lipid-based NPs exhibit the capacity to breach the BBB via receptor-mediated transcytosis and surface modifications. By capitalizing on enhanced permeability and retention, they ensure efficient transport and accumulation within the brain, which has profound implications in neuroscience and therapeutics. Lipid-based NPs facilitate targeted drug delivery to specific brain regions, enhance therapeutic outcomes, and minimize off-target effects. Combining NPs with techniques such as ultrasound or gene editing shows promise for addressing transport challenges. However, realizing their full potential demands further research, including scalable manufacturing, understanding the long-term CNS fate, and establishing reliable BBB models. These advancements promise secure and effective utilization of lipid-based NPs in CNS therapeutics, ultimately advancing patient care and neuroscience. In conclusion, this review highlights the significant potential to overcome the BBB and enable effective CNS drug delivery. The unprecedented opportunities presented by these NPs have the potential to revolutionize the treatment of neurological disorders, heralding a new era of therapeutic interventions.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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