The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review.

IF 4.8 3区医学 Q2 CELL BIOLOGY Inflammation Research Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI:10.1007/s00011-024-01900-w

Shiyu Jin, Sheng Wan, Renxue Xiong, Yujie Li, Tingru Dong, Cuiping Guan

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Abstract

Background: Regulatory T cells (Tregs) play vital roles in controlling immune reactions and maintaining immune tolerance in the body. The targeted destruction of epidermal melanocytes by activated CD8⁺T cells is a key event in the development of vitiligo. However, Tregs may exert immunosuppressive effects on CD8⁺T cells, which could be beneficial in treating vitiligo.

Methods: A comprehensive search of PubMed and Web of Science was conducted to gather information on Tregs and vitiligo.

Results: In vitiligo, there is a decrease in Treg numbers and impaired Treg functions, along with potential damage to Treg-related signaling pathways. Increasing Treg numbers and enhancing Treg function could lead to immunosuppressive effects on CD8⁺T cells. Recent research progress on Tregs in vitiligo has been summarized, highlighting various Treg-related therapies being investigated for clinical use. The current status of Treg-related therapeutic strategies and potential future directions for vitiligo treatment are also discussed.

Conclusions: A deeper understanding of Tregs will be crucial for advancing Treg-related drug discovery and treatment development in vitiligo.

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调节性 T 细胞在白癜风中的作用及治疗进展：微型综述。

背景：调节性 T 细胞（Tregs调节性 T 细胞（Tregs）在控制免疫反应和维持机体免疫耐受方面发挥着重要作用。活化的 CD8+T 细胞有针对性地破坏表皮黑色素细胞是白癜风发病的关键因素。然而，Tregs可能会对CD8+T细胞产生免疫抑制作用，从而有利于治疗白癜风：方法：对PubMed和Web of Science进行了全面搜索，以收集有关Tregs和白癜风的信息：结果：在白癜风患者中，Treg数量减少，Treg功能受损，与Treg相关的信号通路也可能受损。增加Treg数量和增强Treg功能可能会对CD8+T细胞产生免疫抑制作用。本文总结了白癜风中Tregs的最新研究进展，重点介绍了正在研究用于临床的各种Treg相关疗法。此外，还讨论了与Treg相关的治疗策略的现状以及未来潜在的白癜风治疗方向：结论：加深对Tregs的了解对于推动Treg相关药物的发现和白癜风治疗方法的开发至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation Research 医学-免疫学

CiteScore

9.90

自引率

1.50%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.