Association of hypertriglyceridemic waist phenotype with metabolic syndrome traits and its diagnostic potential to predict metabolic syndrome in adults with excess body weight: A community-based cross-sectional study

IF 2.9 3区医学 Q3 NUTRITION & DIETETICS Journal of Human Nutrition and Dietetics Pub Date : 2024-06-04 DOI:10.1111/jhn.13332

Keddagoda Gamage Piyumi Wasana, Nayomi Deshani De Silva, Anoja Priyadarshani Attanayake, Thilak Priyantha Weerarathna

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Abstract

Background

The hypertriglyceridemic waist (HTGW) phenotype is a simple measure to identify individuals at increased risk of metabolic syndrome (MetS) traits. The present study aimed to describe the HTGW prevalence, and its associations with MetS traits, and also determine the diagnostic potential of the mirror indices of HTGW phenotype to predict MetS and its components in community-dwelling adults with overweight or obesity in Southern, Sri Lanka.

Methods

In a cross-sectional study, 300 adults with excess body weight (body mass index >23 kg/m²) were enrolled and examined for the HTGW phenotype (fasting plasma triglyceride concentration ≥1.695 mmol/L and waist circumference >90 and >85 cm in males and females, respectively).

Results

One in five adults with excess body weight had the HTGW phenotype. Phenotype-positive adults had significantly higher fasting plasma glucose (FPG) (p = 0.010), low-density lipoprotein cholesterol (HDL-C) (p < 0.001), total cholesterol (p < 0.001), atherogenic index (p < 0.001), coronary risk index (p = 0.001), triglyceride glucose index (p = 0.040), bioimpedance visceral fat (p = 0.041) and significantly lower HDL-C (p = 0.001) and cardioprotective index (p = 0.009) than those without the HTGW phenotype. Adults with excess body weight and the HTGW phenotype had an increased risk of FPG (odds ratio [OR] = 1.294; 95% confidence interval [CI] 1.051–1.594), atherogenic index (OR = 3.138; 95% CI = 1.559–6.317) and triglyceride glucose index (OR = 3.027; 95% CI = 1.111–8.249). The HTGW phenotype was strongly associated with MetS traits (OR = 16.584; 95% CI = 6.230–44.147). The cut-off values for the product of waist circumference × triglyceride, to identify the risk of having MetS and dyslipidemia among adults with excess body weight were 158.66 and 160.15 cm × mmol/L, respectively.

Conclusions

The readily available and inexpensive measures of the HTGW phenotype could serve as a clinically useful marker to identify MetS traits in adults with excess body weight.

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高甘油三酯腰围表型与代谢综合征特征的关联及其预测体重超标成人代谢综合征的诊断潜力：一项基于社区的横断面研究。

背景：高甘油三酯腰围（HTGW）表型是识别代谢综合征（MetS）特质风险增加个体的一种简单测量方法。本研究旨在描述 HTGW 患病率及其与 MetS 特征的关联，并确定 HTGW 表型镜像指数的诊断潜力，以预测斯里兰卡南部社区超重或肥胖成年人中的 MetS 及其组成部分：在一项横断面研究中，300 名体重超标（体重指数大于 23 kg/m2）的成年人被纳入研究，并接受了 HTGW 表型（空腹血浆甘油三酯浓度≥1.695 mmol/L，男性和女性腰围分别大于 90 cm 和大于 85 cm）检查：每五名体重超标的成年人中就有一人具有 HTGW 表型。表型阳性成人的空腹血浆葡萄糖（FPG）（p = 0.010）、低密度脂蛋白胆固醇（HDL-C）（p 结论：HTGW 表型阳性成人的空腹血浆葡萄糖（FPG）（p = 0.010）、低密度脂蛋白胆固醇（HDL-C）（p = 0.010HTGW表型的测量方法易于获得且成本低廉，可作为临床有用的标记物，用于识别体重超标成人的 MetS 特征。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.