Exfoliated dermatitis and hepatitis to first line Anti-Tubercular Therapy with treatment of Drug-Sensitive Tuberculosis with second line Anti-Tubercular Therapy: a roller coaster ride

Chest disease reports Pub Date : 2024-06-03 DOI:10.4081/cdr.12.12626

S. Spalgais, Ahmed Safwan M., P. Mrigpuri, Raj Kumar

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Abstract

The Adverse Drug Reactions (ADRSs) to Anti-Tubercular Therapy (ATT) have been reported from 8% to 85% worldwide, while the prevalence of ADRSs to 1st line ATT from India reported 2.3% to 17%, with more during the intensive phase and daily regime. However, cutaneous ADRSs related to ATT are less commonly seen. Common cutaneous ADRSs are maculopapular rash, urticarial, erythema multiforme, exfoliative dermatitis, and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Among the 1st line ATT, pyrazinamide is the most common cause at 2.38%, and isoniazid is reported the least at 0.98%. Exfoliated dermatitis is rarely seen with 1st line ATT therapy limited to some case reports and case series.

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用一线抗结核疗法治疗剥脱性皮炎和肝炎，用二线抗结核疗法治疗对药物敏感的结核病：过山车之旅

据报道，全球抗结核疗法（ATT）的药物不良反应（ADRSs）发生率为 8%至 85%，而印度报道的一线 ATT 药物不良反应发生率为 2.3%至 17%，其中强化阶段和每日治疗期间的发生率更高。然而，与 ATT 相关的皮肤 ADRS 并不常见。常见的皮肤 ADRS 包括斑丘疹、荨麻疹、多形性红斑、剥脱性皮炎和伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）。在一线抗逆转录病毒药物中，吡嗪酰胺是最常见的致病原因，占 2.38%，异烟肼最少，占 0.98%。剥脱性皮炎在一线 ATT 治疗中很少见，仅限于一些病例报告和病例系列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chest disease reports

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