Current understanding of free fatty acids and their receptors in colorectal cancer treatment

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS Nutrition Research Pub Date : 2024-07-01 DOI:10.1016/j.nutres.2024.05.007

Agata Binienda, Jakub Fichna

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Currently, dietary factors are being emphasized in the pathogenesis of CRC. There is strong evidence that fatty acids (FAs) and free FA receptors (FFARs) are involved in CRC. This comprehensive review discusses the role of FAs and their receptors in CRC pathophysiology, development, and treatment. In particular, butyrate and n-3 polyunsaturated fatty acids have been found to exert anticancer properties by, among others, inhibiting proliferation and metastasis and inducing apoptosis in tumor cells. Consequently, they are used in conjunction with conventional therapies. Furthermore, FFAR gene expression is down-regulated in CRC, suggesting their suppressive character. Recent studies showed that the FFAR4 agonist, GW9508, can inhibit tumor growth. In conclusion, natural as well as synthetic FFAR ligands are considered promising candidates for CRC therapy.

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目前对游离脂肪酸及其受体在结直肠癌治疗中作用的认识

大肠癌（CRC）是导致癌症相关死亡的主要原因之一。目前，饮食因素在 CRC 发病机制中的作用受到重视。有确凿证据表明，脂肪酸（FAs）和游离脂肪酸受体（FFARs）与 CRC 有关。本综述讨论了脂肪酸及其受体在 CRC 病理生理学、发展和治疗中的作用。尤其是丁酸盐和 n-3 多不饱和脂肪酸，它们通过抑制肿瘤细胞的增殖和转移以及诱导肿瘤细胞凋亡等方式发挥抗癌作用。因此，它们与传统疗法结合使用。此外，FFAR 基因在 CRC 中表达下调，表明其具有抑制作用。最近的研究表明，FFAR4 激动剂 GW9508 可以抑制肿瘤生长。总之，天然和合成的 FFAR 配体被认为是治疗 CRC 的有前途的候选药物。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.