Bifunctional iron-porphyrin metal-organic frameworks for organic photoelectrochemical transistor gating and biosensing

Abstract

Iron-porphyrin metal-organic frameworks (MOFs) have emerged as a remarkable class of semiconductors with adjustable photoelectrical properties and peroxidase-mimicking activities, yet their full potential remains largely unexplored. The organic photoelectrochemical transistor (OPECT) has been proven to be a prominent platform for diverse applications. Herein, iron-porphyrin MOFs, as bifunctional photo-gating module and horseradish peroxidase-mimicking nanozyme, is explored for novel OPECT bioanalysis. Exemplified by alpha-fetoprotein (AFP)-dependent sandwich immunorecognition and therein glucose oxidase (GOx)-generated H₂O₂ to etch CdS quantum dots on the surface of iron-porphyrin MOFs, this OPECT bioanalysis achieved high-performance AFP detection with a low detection limit of 24 fg/mL. This work featured a bifunctional iron-porphyrin MOFs gated OPECT, which is envisioned to inspire more interest in developing the diverse MOFs-nanozymes toward novel optoelectronics and beyond.