Enhancing orthodontic treatment control with fish scale-derived hydroxyapatite nanoparticles: Insights from an animal model study

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Saudi Dental Journal Pub Date : 2024-08-01 DOI:10.1016/j.sdentj.2024.06.007

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Abstract

Objectives

This study investigates the impact of injected fish-scale-derived hydroxyapatite nanoparticles (FsHA-NPs) on orthodontic tooth movement (OTM) and the width of the periodontal ligament (PDL) space.

Materials and Methods

Twenty-six Wistar rats underwent mesial orthodontic traction with a force of 50 g for 21 days. Following the application of the orthodontic appliance, the rats were randomly divided into two groups: a control group, which received a 0.3 µg saline injection, and the experimental FsHA group, which received 100 mg/0.3 ml of FsHA-NPs after thorough characterisation. Injections were administered immediately after appliance application and repeated at 7 and 14 days. Statistical analysis was conducted with a significance level of P ≤ 0.05.

Result

The experimental group exhibited a significant reduction in OTM at 7-, 14-, and 21-day post-force application. Additionally, a reduction in PDL width was observed in the mesiocervical and disto-apical regions of the mesial and distal roots of the first molar.

Conclusion

FsHA-NPs derived from biowaste fish scales exhibit promising potential as biomaterials for enhancing control over OTM. This study underscores the viability, accessibility, and safety of FsHA-NPs as a locally injectable material for orthodontic applications.

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利用源自鱼鳞的羟基磷灰石纳米颗粒加强正畸治疗控制：动物模型研究的启示

材料与方法26 只 Wistar 大鼠接受了为期 21 天、力为 50 g 的中侧正畸牵引。戴上正畸矫治器后，大鼠被随机分为两组：对照组和实验 FsHA 组，对照组接受 0.3 µg 生理盐水注射，实验 FsHA 组接受 100 毫克/0.3 毫升经彻底鉴定的 FsHA-NPs 注射。在使用药物后立即注射，并在 7 天和 14 天后重复注射。结果实验组在矫治后 7 天、14 天和 21 天的 OTM 显著减少。结论从生物废料鱼鳞中提取的 FsHA-NPs 具有作为生物材料增强对 OTM 控制的潜力。这项研究强调了 FsHA-NPs 作为局部注射材料在正畸应用中的可行性、可及性和安全性。

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来源期刊

Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.